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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hgftm1Jmw
targeted mutation 1, James M Wilson
MGI:3574633
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Hgftm1Jmw/Hgftm1Jmw involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3716970
cn2
 		Hgftm1Jmw/Hgftm1Jmw
Tg(Pax2-cre)1Akg/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 MGI:6446739
cn3
 		Hgftm1Jmw/Hgftm1Jmw
Tg(Mx1-cre)29-4Her/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL MGI:3716971
cn4
 		Hgftm1Jmw/Hgftm1Jmw
Rag2tm1Fwa/Rag2tm1Fwa 		involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3716969


Genotype
MGI:3716970
cn1
Allelic
Composition		 Hgftm1Jmw/Hgftm1Jmw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hgftm1Jmw mutation (1 available); any Hgf mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
decreased hepatocyte proliferation ( J:97145 )
• with CCl4 treatment, adenocre administration, and GdCl3 10 days post-cre treatment to reduce Kuppfler cells, a major reduction in hepatocyte DNA synthesis is observed (1.8-2-fold reduction in BrdU incorporation)

cellular
decreased hepatocyte proliferation ( J:97145 )
• with CCl4 treatment, adenocre administration, and GdCl3 10 days post-cre treatment to reduce Kuppfler cells, a major reduction in hepatocyte DNA synthesis is observed (1.8-2-fold reduction in BrdU incorporation)




Genotype
MGI:6446739
cn2
Allelic
Composition		 Hgftm1Jmw/Hgftm1Jmw
Tg(Pax2-cre)1Akg/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hgftm1Jmw mutation (1 available); any Hgf mutation (55 available)
Tg(Pax2-cre)1Akg mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
abnormal strial intermediate cell morphology ( J:289982 )
• reduction in future strial intermediate cells

pigmentation
abnormal strial intermediate cell morphology ( J:289982 )
• reduction in future strial intermediate cells




Genotype
MGI:3716971
cn3
Allelic
Composition		 Hgftm1Jmw/Hgftm1Jmw
Tg(Mx1-cre)29-4Her/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hgftm1Jmw mutation (1 available); any Hgf mutation (55 available)
Tg(Mx1-cre)29-4Her mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
decreased hepatocyte proliferation ( J:97145 )
• liver regenerative capacity (assessed by BrdU incorporation) is decreased 1.5-fold following pI:pC treatment and CCl4 administration, compared to controls receiving PBS and CCl4 treatment
impaired liver regeneration ( J:97145 )
• 6-8 week old mice treated with poly I:C to induce cre expression, treated with CCl4 to induce liver injury show decreased liver regenerative capacity (~1.5-fold decrease)

cellular
decreased hepatocyte proliferation ( J:97145 )
• liver regenerative capacity (assessed by BrdU incorporation) is decreased 1.5-fold following pI:pC treatment and CCl4 administration, compared to controls receiving PBS and CCl4 treatment




Genotype
MGI:3716969
cn4
Allelic
Composition		 Hgftm1Jmw/Hgftm1Jmw
Rag2tm1Fwa/Rag2tm1Fwa
Genetic
Background		 involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hgftm1Jmw mutation (1 available); any Hgf mutation (55 available)
Rag2tm1Fwa mutation (45 available); any Rag2 mutation (119 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
decreased hepatocyte proliferation ( J:97145 )
• with CCl4 treatment, adenocre administration, and GdCl3 10 days post-cre treatment to reduce Kuppfler cells, a major reduction in hepatocyte DNA synthesis is observed (1.8-2-fold reduction in BrdU incorporation)
impaired liver regeneration ( J:97145 )
• 6-8 week-old mice treated with adeno-cre to delete HGF receiving CCl4 to induce liver injury and GdCl3 either 24 hours prior to and with cre treatment or 10 days post-cre treatment to reduce Kuppfler cell numbers show significantly reduced liver regeneration capacity

cellular
decreased hepatocyte proliferation ( J:97145 )
• with CCl4 treatment, adenocre administration, and GdCl3 10 days post-cre treatment to reduce Kuppfler cells, a major reduction in hepatocyte DNA synthesis is observed (1.8-2-fold reduction in BrdU incorporation)




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory