Analysis Tools
behavior/neurological
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• mutants respond to brief periods of dim red light during the light period with vigorous wheel-running unlike wild-type mice
• the time of onset of activity at the beginning of the dark period is more variable
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• in about 1/3 of homozygotes in DD conditions a rhythmic component can be discerned and it is in direct antiphase with the prior light-dark cycle
(J:96895)
• the peak of activity is in antiphase to the prior LD cycle
(J:97146)
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• in about 2/3 of homozygotes in DD conditions no circadian rhythm in wheel-running behavior is seen
(J:96895)
• with continuous dim red light homozygotes display only weak rhythmic activity with no clear time of onset
(J:97146)
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• homozygotes re-entrain more rapidly to an 8 hour shift in the LD cycle (2.4 days compared to 6.7 days to complete entrainment in wild-type mice)
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hematopoietic system
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• serum levels of IgE are lower after immunization with TNP-KLH than levels in wild-type
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immune system
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• serum levels of IgE are lower after immunization with TNP-KLH than levels in wild-type
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• magnitude of immediate cutaneous reaction to TNP-CGG is reduced compared to wild-type animals
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• mice sensitized with the hapten NP OSu show significantly greater footpad swelling at 24 and 48 hours after challenge than wild-type
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• ratios of CD4+ T cell secretion of Ifng to IL4 are significantly higher than those in wild-type at 24 and 96 hours
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• stimulated splenic CD4+ T cells produce 360 and 676% of the levels observed in wild-type cells at 24 and 96 hours
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• stimulation of CD4+ splenic T cells with anti-CD3 plus anti-CD28 antibodies results in 3.6- and 4.7-fold higher secretion at 24 and 96 hours respectively relative to wild-type cells
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• stimulated splenic CD4+ T cells produce 62 and 25% of the levels observed in wild-type cells at 24 and 96 hours
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