All Phenotypes Bmpr2<tm1.2Enl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Bmpr2^tm1.2Enl
targeted mutation 1.2, En Li
MGI:3574813

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bmpr2^tm1.2Enl/Bmpr2^tm1.2Enl	involves: 129S4/SvJae * C57BL/6	MGI:3574956
cn2	Bmpr2^tm1.1Enl/Bmpr2^tm1.2Enl H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129S4/SvJae * C57BL/6J * CBA/J	MGI:5558941

Allelic Composition	Bmpr2^tm1.2Enl/Bmpr2^tm1.2Enl
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr2^tm1.2Enl mutation (0 available); any Bmpr2 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:97109 )

• homozygous embryos die during gastrulation

growth/size/body

embryonic growth retardation ( J:97109 )

• exhibit severe growth retardation at E7.5

embryo

embryonic growth retardation ( J:97109 )

• exhibit severe growth retardation at E7.5

Allelic Composition	Bmpr2^tm1.1Enl/Bmpr2^tm1.2Enl H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr2^tm1.1Enl mutation (1 available); any Bmpr2 mutation (46 available)
Bmpr2^tm1.2Enl mutation (0 available); any Bmpr2 mutation (46 available)
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:206541 )

N	• mice exhibit normal maxillary and mandibular branches of the trigeminal nerve

abnormal ophthalmic nerve morphology ( J:206541 )

• stunted and prematurely branched at E11.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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