Phenotypes associated with this allele

• Allele Symbol: Zic5^tm1Sia
• Allele Name: targeted mutation 1, Shinichi Aizawa
• Allele ID: MGI:3574814
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zic5^tm1Sia/Zic5^tm1Sia	involves: C57BL/6 * CBA	MGI:3574833

Genotype
MGI:3574833

hm1

• Allelic Composition: Zic5^tm1Sia/Zic5^tm1Sia
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:97076 )

• most mutants were live-born but died within 24 hours

craniofacial

absent mandible ( J:97076 )

• 2 out of 68 embryos exhibited agnathia

micrognathia ( J:97076 )

• one fifth of embryos exhibited mild micrognathia

skeleton

absent mandible ( J:97076 )

• 2 out of 68 embryos exhibited agnathia

micrognathia ( J:97076 )

• one fifth of embryos exhibited mild micrognathia

vision/eye

abnormal optic vesicle formation ( J:97076 )

• preoptic area was somewhat reduced medially in E12.5 and E18.5 embryos

microphthalmia ( J:97076 )

• found in some mutants

anophthalmia ( J:97076 )

• found in some mutants

nervous system

abnormal forebrain development ( J:97076 )

• subtle defects in the ventromedial region of the forebrain at E12.5

abnormal hippocampus development ( J:97076 )

• development of hippocampus was somewhat poor at E18.5

abnormal telencephalon development ( J:97076 )

• subtle defects in the dorsomedial region of the telencephalon at E12.5

• rostrally, development of the septum was poor at E12.5 and E18.5 and the fornix that normally becomes remarkable in septum at E15 was hardly visible

abnormal folding of telencephalic vesicles ( J:97076 )

• invagination of the telencephalic roof was less pronounced at E12.5

dilated lateral ventricle ( J:97076 )

• the septum, striatum, and pallidum were underdeveloped, causing expansion of lateral ventricles at E18.5

abnormal choroid plexus morphology ( J:97076 )

• choroid plexus was distorted at E12.5

dilated third ventricle ( J:97076 )

• at E18.5, the thalamus, hypothalamus, and preoptic area were reduced in the medial region, resulting in the expansion of the third ventricle

abnormal globus pallidus morphology ( J:97076 )

• swelling of the pallidum was poor mediocaudally at E12.5 and was underdeveloped at E18.5

abnormal striatum morphology ( J:97076 )

• swelling of the striatum was poor mediocaudally at E12.5 and was underdeveloped at E18.5

abnormal hypothalamus morphology ( J:97076 )

• hypothalamus was reduced medially in E12.5 and E18.5 embryos

small thalamus ( J:97076 )

• swelling of the thalamus was poor ventrally at E15 and at E18.5 the thalamus was reduced in the medial region

abnormal cerebral cortex morphology ( J:97076 )

• reduced medial pallium at E12.5

• the cortex was thinner at E18.5

exencephaly ( J:97076 )

• observed in 9% of mutant embryos

abnormal axon morphology ( J:97076 )

• the fornix that normally becomes remarkable in septum at E15 was hardly visible

abnormal cranial ganglia morphology ( J:97076 )

• mild reduction in facial ganglia

abnormal glossopharyngeal ganglion morphology ( J:97076 )

• mild reduction in glossopharyngeal ganglia

abnormal trigeminal ganglion morphology ( J:97076 )

• mild reduction in trigeminal ganglia

growth/size/body

microcephaly ( J:97076 )

• most mutants were microcephalic