All Phenotypes Grm8<tm1En> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Grm8^tm1En
targeted mutation 1, Eric S Nisenbaum
MGI:3574927

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grm8^tm1En/Grm8^tm1En	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3575694

Allelic Composition	Grm8^tm1En/Grm8^tm1En
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grm8^tm1En mutation (0 available); any Grm8 mutation (68 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:97019 )

• in hippocampal slice cultures for electrophysiological recording of excitatory postsynaptic potentials, mutant brain was insensitive to selective group III mGlue receptor agonist, L-AP4, and the group II agonist, LY379268

• however, no abnormalities were observed in body weights, or in autonomic function and sensorimotor responses

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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