Analysis Tools
neoplasm
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• at 10-12 months, enlarged livers with multiple tumors were seen in 100% (12/12) mutant mice
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• at 10-12 months, enlarged livers with multiple tumors were seen in 100% (12/12) mutant mice
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homeostasis/metabolism
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• at 4 weeks
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immune system
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• infiltration of inflammatory cells are seen in 4 weeks old mutant mice liver
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liver/biliary system
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• infiltration of inflammatory cells are seen in 4 weeks old mutant mice liver
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• note: apoptotic cells and necrosis are seen in 4 weeks old mutant mice liver
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• at 4 weeks, fatty vacuolated cells in liver had a 3-fold elevation in triglyceride levels
• lipid accumulation was also seen in cultures of primary hepatocytes derived from mutant mice
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• at 10-12 months, enlarged livers with multiple tumors were seen in 100% (12/12) mutant mice
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• at 10-12 months, enlarged livers with multiple tumors were seen in 100% (12/12) mutant mice
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• pericentral and pericellular fibrosis was seen in older animals
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| hepatocellular carcinoma | DOID:684 |
OMIM:114550 |
J:97188 | |
