Phenotypes associated with this allele

• Allele Symbol: Dnmt3l^tm1Scot
• Allele Name: targeted mutation 1, Hamish S Scott
• Allele ID: MGI:3574947
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dnmt3l^tm1Scot/Dnmt3l^tm1Scot	C57BL/6-Dnmt3l^tm1Scot	MGI:3575019

Genotype
MGI:3575019

hm1

• Allelic Composition: Dnmt3l^tm1Scot/Dnmt3l^tm1Scot
• Genetic Background: C57BL/6-Dnmt3l^tm1Scot

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

azoospermia ( J:97190 )

♂ • germ cells are lost through apoptosis and sloughing with many tubules containing only Sertoli cells

arrest of male meiosis ( J:97190 )

♂ • at P14 in first spermatogenic wave a build up of leptotene and zygotene spermatocytes is seen with no cells progressing beyond stage IV

♂ • at P70 only leptotene spermatocytes and spermatogonia are present

♂ • the pachytene synaptonemal complex is not seen

abnormal seminiferous tubule epithelium morphology ( J:97190 )

♂ • the epithelium has a vacuolated appearance

small gonad ( J:97190 )

• adults display severe hypogonadism

infertility ( J:97190 )

endocrine/exocrine glands

abnormal seminiferous tubule epithelium morphology ( J:97190 )

♂ • the epithelium has a vacuolated appearance

cellular

azoospermia ( J:97190 )

♂ • germ cells are lost through apoptosis and sloughing with many tubules containing only Sertoli cells

arrest of male meiosis ( J:97190 )

♂ • at P14 in first spermatogenic wave a build up of leptotene and zygotene spermatocytes is seen with no cells progressing beyond stage IV

♂ • at P70 only leptotene spermatocytes and spermatogonia are present

♂ • the pachytene synaptonemal complex is not seen