Phenotypes associated with this allele

• Allele Symbol: Tg(Sftpc-cre)1Blh
• Allele Name: transgene insertion 1, Brigid L Hogan
• Allele ID: MGI:3574949
• Summary: 18 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Bax^tm1Sjk/Bax^tm1Sjk Bmpr1a^tm1Bhr/Bmpr1a^tm2.1Bhr Tg(Sftpc-cre)1Blh/0	involves: 129 * C57BL/6 * DBA/2 * ICR	MGI:3811313
cn2	Mycn^tm1Psk/Mycn^+ Tg(Sftpc-cre)1Blh/0	involves: 129 * C57BL/6 * ICR	MGI:3575016
cn3	Mycn^tm1Psk/Mycn^tm1Psk Tg(Sftpc-cre)1Blh/0	involves: 129 * C57BL/6 * ICR	MGI:3575015
cn4	Hoxa5^tm1.1Ljea/Hoxa5^tm1.1Ljea Tg(Sftpc-cre)1Blh/0	involves: 129 * C57BL/6J * DBA/2 * SJL	MGI:6404241
cn5	Hoxa5^tm1.1Ljea/Hoxa5^+ Tg(Sftpc-cre)1Blh/0	involves: 129 * C57BL/6J * DBA/2 * SJL	MGI:6404242
cn6	Jun^tm4Wag/Jun^tm4Wag Tg(Sftpc-cre)1Blh/0	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:5306592
cn7	Fgf4^tm1.2Mrt/Fgf4^tm1.2Mrt Tg(Sftpc-cre)1Blh/0	involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * ICR	MGI:3811321
cn8	Adgrf5^tm1.1Bstc/Adgrf5^tm1.2Bstc Tg(Sftpc-cre)1Blh/0	involves: 129S4/SvJae * C57BL/6 * C57BL/6J * DBA/2	MGI:5490535
cn9	Atp1b1^tm1.1Zboro/Atp1b1^tm1.1Zboro Tg(Sftpc-cre)1Blh/0	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2	MGI:5788091
cn10	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^+ Tg(Sftpc-cre)1Blh/0	involves: 129S4/SvJaeSor * C57BL/6 * DBA/2	MGI:5052295
cn11	Bmp4^tm3.1Blh/Bmp4^+ Tg(Sftpc-cre)1Blh/0	involves: 129S6/SvEvTac * C57BL/6 * DBA/2	MGI:3811315
cn12	Bmpr1a^tm2.1Bhr/Bmpr1a^+ Tg(Sftpc-cre)1Blh/0	involves: 129S7/SvEvBrd * C57BL/6 * DBA/2	MGI:3811322
cn13	Bmpr1a^tm1Bhr/Bmpr1a^tm2.1Bhr Tg(Sftpc-cre)1Blh/0	involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 * ICR	MGI:3811312
cn14	Bmpr1a^tm2.1Bhr/Bmpr1a^+ Tg(Sftpc-cre)1Blh/0	involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 * ICR	MGI:3811314
cn15	Gt(ROSA)26Sor^tm1(CAG-Sox2,-EGFP)Blh/Gt(ROSA)26Sor^+ Tg(Sftpc-cre)1Blh/0	involves: 129S/SvEv * C57BL/6 * DBA/2	MGI:4820810
cn16	Fgfr2^tm1Dor/Fgfr2^tm1Dor Tg(Sftpc-cre)1Blh/0	involves: 129X1/SvJ * C57BL/6 * DBA/2	MGI:3851800
cn17	Adora2b^tm1Msit/Adora2b^tm1Msit Tg(Sftpc-cre)1Blh/0	involves: C57BL/6 * DBA/2	MGI:6151087
tg18	Tg(Sftpc-cre)1Blh/0	involves: C57BL/6 * DBA/2	MGI:6404239

Genotype
MGI:3811313

cn1

• Allelic Composition: Bax^tm1Sjk/Bax^tm1Sjk; Bmpr1a^tm1Bhr/Bmpr1a^tm2.1Bhr; Tg(Sftpc-cre)1Blh/0
• Genetic Background: involves: 129 * C57BL/6 * DBA/2 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

abnormal lung development ( J:106392 )

• while increased apoptosis of epithelial cells is rescued, mice exhibit abnormal branching morphogenesis

Genotype
MGI:3575016

cn2

• Allelic Composition: Mycn^tm1Psk/Mycn⁺; Tg(Sftpc-cre)1Blh/0
• Genetic Background: involves: 129 * C57BL/6 * ICR

mortality/aging

decreased survivor rate ( J:97215 )

• ~50% of mutants develop normally into adulthood with no obvious lung defects

neonatal lethality, incomplete penetrance ( J:97215 )

• ~50% of mutants die at or shortly after birth with a severe lung phenotype

respiratory system

abnormal lung morphology ( J:97215 )

• at E18.5 the lungs of affected mutants are composed of numerous large fluid-filled sacs containing cellular debris lined by highly attenuated epithelial cells separated by a thin layer of mesoderm

• however, lung size, lobulation pattern, and trachea morphology are normal

abnormal lung development ( J:97215 )

• at E15.5-E16.5, a reduction in the proportion of proliferating cells in the endoderm is seen

• at E15.5, E16.5 and E18.5, abundant apoptotic cells are detected in the lumen, epithelium and mesenchyme, unlike in wild-type lungs

abnormal branching involved in lung morphogenesis ( J:97215 )

• at E14.5-E16.5 in affected mutants, branching is reduced with only a few expanded tubes separated by abundant mesoderm present

abnormal lung epithelium morphology ( J:97215 )

• at E14.5, E15.5 and E18.5, epithelial cell size is irregular, dead cells are seen in the lumen, and increased apoptosis is seen

decreased type I pneumocyte number ( J:97215 )

• at E18.5, attenuated presumptive type I cells are lining the large sacs

decreased type II pneumocyte number ( J:97215 )

• at E18.5, a paucity of type II cells is observed in the mutant lung

Genotype
MGI:3575015

cn3

• Allelic Composition: Mycn^tm1Psk/Mycn^tm1Psk; Tg(Sftpc-cre)1Blh/0
• Genetic Background: involves: 129 * C57BL/6 * ICR

mortality/aging

neonatal lethality, complete penetrance ( J:97215 )

• all mutants die at birth

respiratory system

abnormal lung morphology ( J:97215 )

• at E18.5 the lungs are composed of numerous large fluid-filled sacs containing cellular debris lined by highly attenuated epithelial cells separated by a thin layer of mesoderm

• however, lung size, lobulation pattern, and trachea morphology are normal

abnormal lung development ( J:97215 )

• at E15.5-E16.5, a reduction in the proportion of proliferating cells in the endoderm is seen (17% compared to 65% in wild-type at E15.5)

• at E15.5, E16.5 and E18.5, abundant apoptotic cells are detected in the lumen, epithelium and mesenchyme, unlike in wild-type lungs

abnormal branching involved in lung morphogenesis ( J:97215 )

• at E14.5-E16.5, branching is reduced with only a few expanded tubes separated by abundant mesoderm present

abnormal lung epithelium morphology ( J:97215 )

• at E14.5, E15.5 and E18.5, epithelial cell size is irregular, dead cells are seen in the lumen, and increased apoptosis is seen

abnormal pulmonary alveolus epithelial cell morphology ( J:97215 )

• expression of Aqp5 (a marker for type I cells) is prematurely increased at E16, suggesting premature differentiation of epithelial cells

decreased type I pneumocyte number ( J:97215 )

• at E18.5, attenuated presumptive type I cells are lining the large sacs

decreased type II pneumocyte number ( J:97215 )

• at E18.5, a paucity of type II cells is observed in the mutant lung

Genotype
MGI:6404241

cn4

• Allelic Composition: Hoxa5^tm1.1Ljea/Hoxa5^tm1.1Ljea; Tg(Sftpc-cre)1Blh/0
• Genetic Background: involves: 129 * C57BL/6J * DBA/2 * SJL

respiratory system

lung cyst ( J:170336 )

• as in mice with only Tg(Sftpc-cre)1Blh

abnormal pulmonary alveolar sac morphology ( J:170336 )

• distended alveoli at the periphery of lobes at day 30 as in mice with only Tg(Sftpc-cre)1Blh

growth/size/body

lung cyst ( J:170336 )

• as in mice with only Tg(Sftpc-cre)1Blh

Genotype
MGI:6404242

cn5

• Allelic Composition: Hoxa5^tm1.1Ljea/Hoxa5⁺; Tg(Sftpc-cre)1Blh/0
• Genetic Background: involves: 129 * C57BL/6J * DBA/2 * SJL

respiratory system

lung cyst ( J:170336 )

• as in mice with only Tg(Sftpc-cre)1Blh

abnormal pulmonary alveolar sac morphology ( J:170336 )

• distended alveoli at the periphery of lobes at day 30 as in mice with only Tg(Sftpc-cre)1Blh

growth/size/body

lung cyst ( J:170336 )

• as in mice with only Tg(Sftpc-cre)1Blh

Genotype
MGI:5306592

cn6

• Allelic Composition: Jun^tm4Wag/Jun^tm4Wag; Tg(Sftpc-cre)1Blh/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

cellular

increased lung apoptosis ( J:179883 )

• mutants exhibit an increase in apoptotic cells in the lungs

respiratory system

increased lung apoptosis ( J:179883 )

• mutants exhibit an increase in apoptotic cells in the lungs

lung inflammation ( J:179883 )

• mutants exhibit infiltration of atypical foamy alveolar macrophages

• mutants with prolonged exposure to cigarette smoke exhibit perivascular and peribronchiolar inflammation

abnormal pulmonary alveolar system morphology ( J:179883 )

• 3 month old mutants exhibit enlarged air spaces and infiltration of atypical foamy alveolar macrophages

• progressive destruction of alveolar tissue

emphysema ( J:179883 )

• mutants develop progressive emphysema

abnormal pulmonary alveolar parenchyma morphology ( J:179883 )

• localized destruction leading to large cavities in the parenchyma

immune system

abnormal cytokine level ( J:179883 )

• elevated levels of IL-12p40, IL-13, and CXCL1 cytokines in the BAL

abnormal tumor necrosis factor level ( J:179883 )

• an elevated level of TNF-alpha is seen in the BAL fluid

lung inflammation ( J:179883 )

• mutants exhibit infiltration of atypical foamy alveolar macrophages

• mutants with prolonged exposure to cigarette smoke exhibit perivascular and peribronchiolar inflammation

homeostasis/metabolism

abnormal cytokine level ( J:179883 )

• elevated levels of IL-12p40, IL-13, and CXCL1 cytokines in the BAL

abnormal tumor necrosis factor level ( J:179883 )

• an elevated level of TNF-alpha is seen in the BAL fluid

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pulmonary emphysema		DOID:9675	OMIM:130700	J:179883

Genotype
MGI:3811321

cn7

• Allelic Composition: Fgf4^tm1.2Mrt/Fgf4^tm1.2Mrt; Tg(Sftpc-cre)1Blh/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * ICR

respiratory system

respiratory system phenotype ( J:106392 )

N • mice exhibit normal lung morphology

Genotype
MGI:5490535

cn8

• Allelic Composition: Adgrf5^tm1.1Bstc/Adgrf5^tm1.2Bstc; Tg(Sftpc-cre)1Blh/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * DBA/2

respiratory system

pulmonary alveolar proteinosis ( J:196943 )

• as in Gpr116^tm1.2Bstc homozygotes

homeostasis/metabolism

pulmonary alveolar proteinosis ( J:196943 )

• as in Gpr116^tm1.2Bstc homozygotes

Genotype
MGI:5788091

cn9

• Allelic Composition: Atp1b1^tm1.1Zboro/Atp1b1^tm1.1Zboro; Tg(Sftpc-cre)1Blh/0
• Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

homeostasis/metabolism

impaired pulmonary alveolar fluid clearance ( J:233742 )

• 78% reduction in alveolar fluid clearance as compared to controls

respiratory system

respiratory system phenotype ( J:233742 )

N • lung permeability, wet-to-dry lung weight ratios and lung morphology are similar to controls

impaired pulmonary alveolar fluid clearance ( J:233742 )

• 78% reduction in alveolar fluid clearance as compared to controls

abnormal respiratory epithelial sodium ion transmembrane transport ( J:233742 )

• IEQ (equivalent short circuit current) is reduced in cultured alveolar epithelial cell monolayers as compared to controls, however, RT (transepithelial electrical resistance) is similar to controls

• cultured alveolar epithelial cell monolayers exhibit lower unidirectional Na+ flux in the apical-to-basolateral direction and unchanged Na+ flux in the basolateral-to-apical direction as compared to controls

• baseline net Na+ absorption is lower than in control monolayers

Genotype
MGI:5052295

cn10

• Allelic Composition: Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺; Tg(Sftpc-cre)1Blh/0
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * DBA/2

respiratory system

lung cyst ( J:170336 )

• large dilated cysts at E18.5

growth/size/body

lung cyst ( J:170336 )

• large dilated cysts at E18.5

Genotype
MGI:3811315

cn11

• Allelic Composition: Bmp4^tm3.1Blh/Bmp4⁺; Tg(Sftpc-cre)1Blh/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

respiratory system

abnormal lung morphology ( J:106392 )

• at E16.5 and E18.5, 50% of mice exhibit abnormal lungs with large sacs

abnormal respiratory system physiology ( J:106392 )

• at E16.5, cell proliferation lung epithelium and mesenchyme is decreased 50% compared to in wild-type mice while apoptosis is increased compared to in wild-type mice

Genotype
MGI:3811322

cn12

• Allelic Composition: Bmpr1a^tm2.1Bhr/Bmpr1a⁺; Tg(Sftpc-cre)1Blh/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

respiratory system

respiratory system phenotype ( J:106392 )

N • Background Sensitivity: unlike on an ICR mixed background, all mice exhibit normal lung morphology

Genotype
MGI:3811312

cn13

• Allelic Composition: Bmpr1a^tm1Bhr/Bmpr1a^tm2.1Bhr; Tg(Sftpc-cre)1Blh/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 * ICR

mortality/aging

postnatal lethality, complete penetrance ( J:106392 )

• all mice die or are euthanized within 2 days of birth due to severe respiratory distress

respiratory system

respiratory system phenotype ( J:106392 )

N • despite defects in distal portions of the lungs, proximal bronchi and bronchioles appear normal

abnormal lung morphology ( J:106392 )

• at E16.5, the distal regions of all four lobes are abnormal

• lungs are highly abnormal with large, fluid-filled (emphysematous) sacs

• however, lungs are normal at E12.5

abnormal lung epithelium morphology ( J:106392 )

• at E16.5, the number of more distal branches is reduced and branches are smaller than in wild-type mice

• epithelial cells in the periphery of the lung have a more rounded morphology than in wild-type mice

• epithelial cells cultured in a mesenchyme-free system fail to undergo secondary branching, develop fewer or no buds and exhibit a collapsed and folded morphology compared to wild-type cultures

decreased type II pneumocyte number ( J:106392 )

• fewer than normal as determined by surfactant C expression

abnormal respiratory system physiology ( J:106392 )

• despite defects in distal portions of the lungs, proximal bronchi and bronchioles appear normal

respiratory distress ( J:106392 )

Genotype
MGI:3811314

cn14

• Allelic Composition: Bmpr1a^tm2.1Bhr/Bmpr1a⁺; Tg(Sftpc-cre)1Blh/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 * ICR

respiratory system

abnormal lung morphology ( J:106392 )

• Background Sensitivity: 46% of mice exhibit lung abnormalities between E16.5, and birth unlike when the transgene is carried on a C57BL/6 background

Genotype
MGI:4820810

cn15

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Sox2,-EGFP)Blh}/Gt(ROSA)26Sor⁺; Tg(Sftpc-cre)1Blh/0
• Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

mortality/aging

premature death ( J:161806 )

• most mice are sacrificed within a few weeks of birth with respiratory distress

respiratory system

abnormal lung morphology ( J:161806 )

• in mice surviving to 15 weeks

increased lung adenocarcinoma incidence ( J:161806 )

• in mice surviving to 15 weeks

bronchiolar epithelial hyperplasia ( J:161806 )

• in mice surviving to 15 weeks

bronchial epithelial hyperplasia ( J:161806 )

• in mice surviving to 15 weeks

lung epithelium hyperplasia ( J:161806 )

• mice that survive to 15 weeks exhibit hyperplasia of the lung epithelium in the bronchi, bronchioles, and alveoli unlike wild-type mice

respiratory distress ( J:161806 )

• within a few weeks of birth

neoplasm

increased lung adenocarcinoma incidence ( J:161806 )

• in mice surviving to 15 weeks

Genotype
MGI:3851800

cn16

• Allelic Composition: Fgfr2^tm1Dor/Fgfr2^tm1Dor; Tg(Sftpc-cre)1Blh/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

embryo

decreased embryo size ( J:150706 )

• E12.5 embryos are noticeably smaller than controls

growth/size/body

decreased embryo size ( J:150706 )

• E12.5 embryos are noticeably smaller than controls

respiratory system

abnormal lung development ( J:150706 )

• apoptosis is expanded caudally in the bronchial epithelium compared to controls at E11.25

• widespread apoptosis occurs in the lung epithelium by E12.5 and is also observed in the lung mesenchyme

impaired branching involved in bronchus morphogenesis ( J:150706 )

• some E11.5 embryos have smaller lung branches with a bumpy, irregular morphology

• by E12.5, irregular outgrowths have arisen along the entire length of both main bronchi of the mutant lungs with outgrowths concentrated more caudally

• mesenchymal protrusions without an accompanying epithelial branch are occasionally observed during embryonic development

Genotype
MGI:6151087

cn17

• Allelic Composition: Adora2b^tm1Msit/Adora2b^tm1Msit; Tg(Sftpc-cre)1Blh/0
• Genetic Background: involves: C57BL/6 * DBA/2

homeostasis/metabolism

increased susceptibility to injury ( J:203572 )

• following acute lung injury, dipyridamole-treated mice exhibit increased PMN trafficking and fail to exhibit a decrease in lung IL6 compared with wild-type mice

Genotype
MGI:6404239

tg18

• Allelic Composition: Tg(Sftpc-cre)1Blh/0
• Genetic Background: involves: C57BL/6 * DBA/2

respiratory system

abnormal lung morphology ( J:170336 )

• enlarged air spaces as early as E15.5

• dilated sacs at the periphery at P6 that may worsen with age

lung cyst ( J:170336 )

abnormal respiratory epithelium physiology ( J:170336 )

• increased apoptosis at E15.5

• 5-fold increase in apoptotic cells at E18.5

growth/size/body

lung cyst ( J:170336 )