Phenotypes associated with this allele

• Allele Symbol: Gnaz^tm1Iah
• Allele Name: targeted mutation 1, I A Hendry
• Allele ID: MGI:3575007
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gnaz^tm1Iah/Gnaz^tm1Iah	C57BL/6JAnu-Gnaz^tm1Iah/AnuApb	MGI:3575891
hm2	Gnaz^tm1Iah/Gnaz^tm1Iah	either: C57BL/6-Gnaz^tm1Iah or (involves: BALB/c * C57BL/6)	MGI:3575895
ht3	Gnaz^tm1Iah/Gnaz^+	C57BL/6JAnu-Gnaz^tm1Iah/AnuApb	MGI:3575896

Genotype
MGI:3575891

hm1

• Allelic Composition: Gnaz^tm1Iah/Gnaz^tm1Iah
• Genetic Background: C57BL/6JAnu-Gnaz^tm1Iah/AnuApb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:97148 )

• morphine treated homozygotes are able to tolerate higher morphine doses compared to wild-type mice (LD50 of 800 mg/kg compared to 700 mg/kg for wild-type)

• no significant difference in the serum levels of morphine or its metabolites is seen

behavior/neurological

decreased chemically-elicited antinociception ( J:97148 )

• in previously unexposed female homozygotes reduced analgesia at low morphine doses is seen, a similar but not significant effect was seen in males

• with repeated morphine doses mutants develop tolerance faster than wild-type mice

reproductive system

reduced fertility ( J:63129 )

• litters from homozygous parents on the C57BL/6 background had increased mortality that was not seen in litters from heterozygous or mixed strain parents

homeostasis/metabolism

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:97148 )

• morphine treated homozygotes are able to tolerate higher morphine doses compared to wild-type mice (LD50 of 800 mg/kg compared to 700 mg/kg for wild-type)

• no significant difference in the serum levels of morphine or its metabolites is seen

Genotype
MGI:3575895

hm2

• Allelic Composition: Gnaz^tm1Iah/Gnaz^tm1Iah
• Genetic Background: either: C57BL/6-Gnaz^tm1Iah or (involves: BALB/c * C57BL/6)

behavior/neurological

abnormal chemically-elicited antinociception ( J:63129 )

• acute morphine administration induces the same degree of antinociception; however homozygotes develop tolerance to morphine more rapidly compared to wild-type mice in the hot and cold plate tests

• spinal mechanisms of morphine tolerance are normal

growth/size/body

decreased body weight ( J:63129 )

• body weight is normal at birth but homozygotes gain less weight and males and females are 22% and 27% smaller than their wild-type littermates at 2 - 3 weeks of age

• After 3 weeks of age homozygotes gain weight more rapidly and the body weight difference is gone by 2 - 3 months of age

Genotype
MGI:3575896

ht3

• Allelic Composition: Gnaz^tm1Iah/Gnaz⁺
• Genetic Background: C57BL/6JAnu-Gnaz^tm1Iah/AnuApb

mortality/aging

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:97148 )

• morphine treated homozygotes are able to tolerate higher morphine doses compared to wild-type mice (LD50 of 750 mg/kg compared to 700 mg/kg for wild-type)

behavior/neurological

abnormal chemically-elicited antinociception ( J:97148 )

• with repeated morphine doses heterozygotes develop tolerance faster than wild-type mice but not as quickly as homozygous mutants

homeostasis/metabolism

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:97148 )

• morphine treated homozygotes are able to tolerate higher morphine doses compared to wild-type mice (LD50 of 750 mg/kg compared to 700 mg/kg for wild-type)