Phenotypes associated with this allele

• Allele Symbol: Grm5^tm1Fcq
• Allele Name: targeted mutation 1, Francois Conquet
• Allele ID: MGI:3575086
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grm5^tm1Fcq/Grm5^tm1Fcq	Not Specified	MGI:3575739

Genotype
MGI:3575739

hm1

• Allelic Composition: Grm5^tm1Fcq/Grm5^tm1Fcq
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to cocaine ( J:97288 )

• show no increased locomotor activity as seen in wildtype following cocaine treatment, despite similar levels of cocaine-induced dopamine levels in the nucleus accumbens as in wildtype

abnormal cocaine consumption ( J:97288 )

• do not self-administer cocaine indicating that reinforcing properties of cocaine are absent in homozygous nulls

nervous system

reduced long-term potentiation ( J:97042 )

• amplitude of corticostriatal long term potentiation is significantly reduced

• corticostriatal long term potentiation is completely blocked when LY 367385, a Grm1 antoagonist, is added