Phenotypes associated with this allele

• Allele Symbol: Sema4a^tm1Kik
• Allele Name: targeted mutation 1, Hutoshi Kikutani
• Allele ID: MGI:3575087
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sema4a^tm1Kik/Sema4a^tm1Kik	either: B6.Cg-Sema4a^tm1Kik or C.Cg-Sema4a^tm1Kik	MGI:3575442
hm2	Sema4a^tm1Kik/Sema4a^tm1Kik	Not Specified	MGI:3706339
cx3	Sema4a^tm1Kik/Sema4a^tm1Kik Sema4d^tm1Kik/Sema4d^tm1Kik	involves: 129P2/OlaHsd	MGI:3706317

Genotype
MGI:3575442

hm1

• Allelic Composition: Sema4a^tm1Kik/Sema4a^tm1Kik
• Genetic Background: either: B6.Cg-Sema4a^tm1Kik or C.Cg-Sema4a^tm1Kik

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal T-helper 1 cell differentiation ( J:97027 )

• T helper 1 cells differentiated poorly in an in vitro assay

abnormal CD4-positive, alpha-beta T cell physiology ( J:97027 )

• in vivo antigen-specific T cell priming and antibody responses against T cell-dependent antigens are impaired

immune system

abnormal T-helper 1 cell differentiation ( J:97027 )

• T helper 1 cells differentiated poorly in an in vitro assay

abnormal CD4-positive, alpha-beta T cell physiology ( J:97027 )

• in vivo antigen-specific T cell priming and antibody responses against T cell-dependent antigens are impaired

abnormal dendritic cell antigen presentation ( J:97027 )

• dendritic cells from mutant poorly stimulated allogenic T cells

decreased susceptibility to type IV hypersensitivity reaction ( J:97027 )

• delayed type hypersensitivity reactions are impaired

abnormal cytokine secretion ( J:97027 )

• production of IFNG by Th1-conditioned cells is reduced

• antigen-induced IL-4 production by CD4+ T cells is increased but IFNG production is decreased

Genotype
MGI:3706339

hm2

• Allelic Composition: Sema4a^tm1Kik/Sema4a^tm1Kik
• Genetic Background: Not Specified

vision/eye

increased retina apoptosis ( J:119485 )

• increased in the outer nuclear layer

absent photoreceptor outer segment ( J:119485 )

• at 4 weeks

retina degeneration ( J:119485 )

cellular

increased retina apoptosis ( J:119485 )

• increased in the outer nuclear layer

nervous system

absent photoreceptor outer segment ( J:119485 )

• at 4 weeks

Genotype
MGI:3706317

cx3

• Allelic Composition: Sema4a^tm1Kik/Sema4a^tm1Kik; Sema4d^tm1Kik/Sema4d^tm1Kik
• Genetic Background: involves: 129P2/OlaHsd

nervous system

nervous system phenotype ( J:119485 )

N • neither defects in the cerebellum nor ectopic granule cells are observed despite being possible ligands for Plxnb2