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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tnfrsf4tm1Mfb
targeted mutation 1, Martin F Bachmann
MGI:3575088
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tnfrsf4tm1Mfb/Tnfrsf4tm1Mfb involves: 129P2/OlaHsd * C57BL/6 MGI:3576367


Genotype
MGI:3576367
hm1
Allelic
Composition		 Tnfrsf4tm1Mfb/Tnfrsf4tm1Mfb
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf4tm1Mfb mutation (0 available); any Tnfrsf4 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal CD4-positive, alpha-beta T cell physiology ( J:59204 )
• after infection with virus CD4+ T cells proliferation and the number of IFN-gamma-producing CD4+ T cells were reduced

normal phenotype
no abnormal phenotype detected ( J:59204 )
• showed normal viability, fertility, growth, anatomy, and lymphocyte subsets in thymus, spleen, lymph nodes, and Peyer's patches

hematopoietic system
abnormal CD4-positive, alpha-beta T cell physiology ( J:59204 )
• after infection with virus CD4+ T cells proliferation and the number of IFN-gamma-producing CD4+ T cells were reduced




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory