All Phenotypes Tg(Acr-EGFP)1Osb MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Acr-EGFP)1Osb
transgene insertion 1, Research Institute for Microbial Diseases, Osaka University
MGI:3575110

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Zp3r^tm1Osb/Zp3r^tm1Osb Tg(Acr-EGFP)1Osb/0	involves: 129S2/SvPas * C3H * C57BL/6	MGI:5430164
cx2	Spaca1^tm1.1Osb/Spaca1^tm1.1Osb Tg(Acr-EGFP)1Osb/0	involves: 129S2/SvPas * C3H * C57BL * C57BL/6 * DBA	MGI:5439284

Allelic Composition	Zp3r^tm1Osb/Zp3r^tm1Osb Tg(Acr-EGFP)1Osb/0
Genetic Background	involves: 129S2/SvPas * C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Acr-EGFP)1Osb mutation (1 available)
Zp3r^tm1Osb mutation (2 available); any Zp3r mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:185779 )

N	• mice exhibit normal acrosomal exocytosis

Allelic Composition	Spaca1^tm1.1Osb/Spaca1^tm1.1Osb Tg(Acr-EGFP)1Osb/0
Genetic Background	involves: 129S2/SvPas * C3H * C57BL * C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spaca1^tm1.1Osb mutation (1 available); any Spaca1 mutation (16 available)
Tg(Acr-EGFP)1Osb mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal spermatogenesis ( J:187685 )

• abnormalities in acrosome formation are detected in spermatids at around step 6

abnormal acrosome morphology ( J:187685 )

• all round-headed testicular and cauda epididymal spermatozoa have an acrosome of negligible size

• a few spermatozoa have small aberrantly shaped acrosomes

globozoospermia ( J:187685 )

abnormal spermatid morphology ( J:187685 )

• as around step 6 nuclei are smaller and accumulation of GFP in the acrosomal granule is not apparent

cellular