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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ly75tm1Mnz
targeted mutation 1, Michel C Nussenzweig
MGI:3575119
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ly75tm1Mnz/Ly75tm1Mnz Not Specified MGI:3575757


Genotype
MGI:3575757
hm1
Allelic
Composition		 Ly75tm1Mnz/Ly75tm1Mnz
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ly75tm1Mnz mutation (1 available); any Ly75 mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal CD8-positive, alpha beta T cell morphology ( J:97290 )
• splenic CD8a+ dendritic cells occur at slightly higher levels while CD8- dendritic cells occur at slightly lower levels
abnormal cytotoxic T cell physiology ( J:97289 )
• cytotoxic lymphocyte response to immunization with foreign splenocytes is absent

immune system
abnormal CD8-positive, alpha beta T cell morphology ( J:97290 )
• splenic CD8a+ dendritic cells occur at slightly higher levels while CD8- dendritic cells occur at slightly lower levels
abnormal cytotoxic T cell physiology ( J:97289 )
• cytotoxic lymphocyte response to immunization with foreign splenocytes is absent




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory