All Phenotypes Lta<hlb382> MGI Mouse

• the absolute numbers of transitional B cells are moderately reduced

decreased NK cell number ( J:134498 )

• the number of NK cells found in the spleen is reduced by 62% compared to wild-type mice

increased leukocyte cell number ( J:82961 )

• increased white blood count on non-fasted whole blood analysis (WBC = 15.39 x 10^3 cells per microliter)

increased B-1b cell number ( J:134498 )

• there is a dramatic increase in the absolute numbers of B1b cells found in the peritoneum compared to wild-type

• the percentage of B1-b cells in the peritoneum is more than 2-fold higher than in wild-type controls

absent marginal zone B cells ( J:134498 )

• there are no marginal zone B cells found in the spleen

absent spleen germinal center ( J:134498 )

• germinal centers are absent from the spleen

absent spleen marginal zone ( J:134498 )

• the marginal zone is absent in the spleen along with having poorly defined T cells and B cell zones

absent Peyer's patches ( J:134498 )

• Peyer's patches are absent in these mice

absent mesenteric lymph nodes ( J:134498 )

• mice lack all mesenteric lymph nodes

absent lymph nodes ( J:134498 )

• mice lack all peripheral and mesenteric lymph nodes and contain no peyer's patches

liver inflammation ( J:134498 )

• small clusters of lymphocytes are observed in the livers of mice

lung inflammation ( J:134498 )

• small clusters of lymphocytes are observed in the lungs of mice