Analysis Tools
growth/size/body
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• due to increased red pulp, spleen is on average 0.84% of body weight instead of 0.56% in controls
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• found at both 3-4 weeks of age and >6 weeks of age likely as part of a comparatively mild compensated anemia
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hematopoietic system
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• due to increased red pulp, spleen is on average 0.84% of body weight instead of 0.56% in controls
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• found at both 3-4 weeks of age and >6 weeks of age likely as part of a comparatively mild compensated anemia
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• increased megakaryocytes in the splenic red pulp and bone marrow
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• 29 x 103/ml in homozygotes instead of 1,039 x 103/ml in wildtype controls or 1,114 x 103/ml in heterozygotes, which is a less severe phenotype than that caused by the scat allele
(J:221899)
• severe thrombocytopenia at both 3-4 weeks of age and >6 weeks of age, but distinct from other alleles in having no pallor or bruising found at birth or postnatally and normal red blood cell counts,
(J:301035)
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• mean platelet volume in homozygotes is 8.7 fL versus 4.7 in wildtype controls and 6.6 in heterozygotes
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• despite normal red blood cell count and hematocrit, white blood cell count in homozygotes is 3.8 x 103 rather than 9.2 x 103 in wildtype controls or 7.6 x 103 in heterozygotes
(J:221899)
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• the average half-life of circulating platelets is only 14 hours compared with 55 hours in controls, and they have an activated phenotype and more immature (reticulated) platelets than normal, indicative of of a high rate of platelet destruction and replacement
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homeostasis/metabolism
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• the average half-life of circulating platelets is only 14 hours compared with 55 hours in controls, and they have an activated phenotype and more immature (reticulated) platelets than normal, indicative of of a high rate of platelet destruction and replacement
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mortality/aging
| N |
• unlike other alleles, homozygotes are generated at expected Mendelian ratios, indicating no prenatal lethality
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immune system
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• due to increased red pulp, spleen is on average 0.84% of body weight instead of 0.56% in controls
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• found at both 3-4 weeks of age and >6 weeks of age likely as part of a comparatively mild compensated anemia
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• despite normal red blood cell count and hematocrit, white blood cell count in homozygotes is 3.8 x 103 rather than 9.2 x 103 in wildtype controls or 7.6 x 103 in heterozygotes
(J:221899)
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