Phenotypes associated with this allele

• Allele Symbol: Scarb1^Hlb398
• Allele Name: heart, lung and blood 398
• Allele ID: MGI:3575158
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scarb1^Hlb398/Scarb1^Hlb398	C57BL/6J-Scarb1^Hlb398	MGI:4360876
ht2	Scarb1^Hlb398/Scarb1^+	C57BL/6J-Scarb1^Hlb398	MGI:4360877
ot3	Scarb1^Hlb398/?	C57BL/6J-Scarb1^Hlb398	MGI:3575257

Genotype
MGI:4360876

hm1

• Allelic Composition: Scarb1^Hlb398/Scarb1^Hlb398
• Genetic Background: C57BL/6J-Scarb1^Hlb398

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal cholesterol homeostasis ( J:152482 )

• clearance of cholesterol ester from the plasma is reduced

• liver uptake of HDL cholesterol ester is reduced, but uptake in other tissues if unaffected

abnormal lipid level ( J:152482 )

increased circulating cholesterol level ( J:152482 )

• 44% increase in total plasma cholesterol level

• free cholesterol is increased

increased circulating HDL cholesterol level ( J:152482 )

• 73% increase in plasma HDL cholesterol

increased circulating phospholipid level ( J:152482 )

increased circulating triglyceride level ( J:152482 )

reproductive system

reproductive system phenotype ( J:152482 )

N • unlike some null mice, fertility is normal

liver/biliary system

abnormal liver physiology ( J:152482 )

• liver uptake of HDL cholesterol ester is reduced, but uptake in other tissues if unaffected

Genotype
MGI:4360877

ht2

• Allelic Composition: Scarb1^Hlb398/Scarb1⁺
• Genetic Background: C57BL/6J-Scarb1^Hlb398

homeostasis/metabolism

increased circulating HDL cholesterol level ( J:152482 )

• intermediate HDL cholesterol levels between homozygous mutant and wild-type mice

Genotype
MGI:3575257

ot3

• Allelic Composition: Scarb1^Hlb398/?
• Genetic Background: C57BL/6J-Scarb1^Hlb398

homeostasis/metabolism

increased circulating cholesterol level ( J:82961 )

• at 8 weeks of age, consuming chow, this animal had a 4 hour fasted total cholesterol of 190 mg/dl; retesting one week later confirmed these results

increased circulating HDL cholesterol level ( J:82961 )

• at 8 weeks of age, consuming chow, this animal had a 4 hour fasted HDL cholesterol of 146 mg/dl; retesting one week later confirmed these results