Analysis Tools|
Allele Symbol Allele Name Allele ID |
Sh2d1atm1Lyin targeted mutation 1, Luo Yin MGI:3575311 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Il2-activated NK cells show less ability to kill some types of CD48+ target cells in vitro
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• Il2-activated NK cells show less ability to kill some types of CD48+ target cells in vitro
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• CD8+ T cell numbers are significantly increased relative to controls after gammaherpesvirus-68 infections
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• deficiency present at all ages
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• levels were consistently lower than normal
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• CD8+ T cell numbers are significantly increased relative to controls after gammaherpesvirus-68 infections
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• deficiency present at all ages
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• levels were consistently lower than normal
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• although response to gammaherpesvirus-68 function was similar to wild-type in that there was no observed mortality and morbidity and acute viral infections were cleared, severe and persistent inflammatory responses were found in lungs and liver that were much slower to resolve
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| X-linked lymphoproliferative syndrome 1 | DOID:0060705 |
OMIM:308240 |
J:97346 | |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 |
• CD8+ T cell numbers are significantly increased relative to controls after gammaherpesvirus-68 infections
|
|
|
• deficiency present at all ages
|
|
|
• levels were consistently lower than normal
|
|
|
• CD8+ T cell numbers are significantly increased relative to controls after gammaherpesvirus-68 infections
|
|
|
• deficiency present at all ages
|
|
|
• levels were consistently lower than normal
|
|
|
• although response to gammaherpesvirus-68 function was similar to wild-type in that there was no observed mortality and morbidity and acute viral infections were cleared, severe and persistent inflammatory responses were found in lungs and liver that were much slower to resolve
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| X-linked lymphoproliferative syndrome 1 | DOID:0060705 |
OMIM:308240 |
J:97346 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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