All Phenotypes Map1b<tm1Prop> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map1b^tm1Prop/Map1b^tm1Prop	involves: 129S1/Sv * 129X1/SvJ	MGI:3575572
hm2	Map1b^tm1Prop/Map1b^tm1Prop	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3575571
cx3	Kif21a^tm1.1Ece/Kif21a⁺ Map1b^tm1Prop/Map1b⁺ Tg(Isl1-EGFP*)1Slp/0	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c * C57BL/6	MGI:6241441
cx4	Map1b^tm1Prop/Map1b^tm1Prop Tg(Isl1-EGFP*)1Slp/0	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6	MGI:6241439

Allelic Composition	Map1b^tm1Prop/Map1b^tm1Prop
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map1b^tm1Prop mutation (0 available); any Map1b mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye morphology ( J:213171 )

• mice exhibit unilateral or bilateral ptosis and/or globe retraction that is 90% penetrant

blepharoptosis ( J:213171 )

• mice exhibit unilateral or bilateral ptosis and/or globe retraction that is 90% penetrant

nervous system

abnormal axon extension ( J:97265 )

• in dorsal root ganglia explants axon outgrowth is wavy/frizzy and covers less area

• dissociated dorsal root ganglion neurons display a curled aspect, have more branching points per neurite, and are more likely to stop growing rather than turn away from a nonpermissive area

cellular

abnormal axon extension ( J:97265 )

• in dorsal root ganglia explants axon outgrowth is wavy/frizzy and covers less area

• dissociated dorsal root ganglion neurons display a curled aspect, have more branching points per neurite, and are more likely to stop growing rather than turn away from a nonpermissive area

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:97423 )

• about 56% of homozygous pups die postnatally

behavior/neurological

decreased exploration in new environment ( J:97423 )

• exploratory activity is absent; however, general activity and gait are normal

growth/size/body

decreased body weight ( J:97423 )

• severely reduced body weight is seen in 94% of homozygous pups

• this body weight reduction is most pronounced before weaning and is decreased later in life through the loss of the most severely affected pups

homeostasis/metabolism

dehydration ( J:97423 )

• homozygotes appear dehydrated and malnourished

reproductive system

reduced fertility ( J:97423 )

• homozygotes are poor breeders

vision/eye

abnormal eye morphology ( J:97423 )

• in 94% of homozygotes one or both eyes appear smaller or retracted; however, eyeball size is normal

• retinal morphology is normal

delayed eyelid opening ( J:97423 )

nervous system

decreased corpus callosum size ( J:97423 )

• in 20% of homozygotes the corpus callosum is thin throughout the brain or absent only in the posterior portions of the forebrain

absent corpus callosum ( J:97423 )

• in 80% of homozygotes agenesis of the corpus callosum is seen

• in the parietal portion of the brain the corpus callosum is replaced by a fine fibrous membrane containing the choroid plexus of the third ventricle

• a longitudinal bundle of myelinated fibers (similar to a Probst bundle) is found in the most medial aspects of the white matter

absent hippocampal commissure ( J:97423 )

abnormal cingulate gyrus morphology ( J:97423 )

• the cingulate gyrus is rotated ventrally

abnormal hippocampus morphology ( J:97423 )

• the hippocampus is dislocated laterally; however, the cortical architecture is normal

abnormal parietal lobe morphology ( J:97423 )

• aberrant bundles of myelinated axons are found in the deeper layers of the parietal cortex

abnormal axon morphology ( J:97423 )

• in the peripheral nerves the number of axons in the intermediate and large size classes are decreased and myelin sheaths of axons within a given size class are thinner; however the overall number of axons is normal

abnormal myelination ( J:97423 )

• in the peripheral nerves myelin sheaths of axons within a given size class are thinner

abnormal nerve conduction ( J:97423 )

• motor nerve conduction velocity is reduced to 19.82 +/- 2.93 compared to 30.60 +/- 6.71 in wild-type mice

integument

delayed hair appearance ( J:97423 )

Allelic Composition	Kif21a^tm1.1Ece/Kif21a⁺ Map1b^tm1Prop/Map1b⁺ Tg(Isl1-EGFP*)1Slp/0
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif21a^tm1.1Ece mutation (0 available); any Kif21a mutation (81 available)
Map1b^tm1Prop mutation (0 available); any Map1b mutation (85 available)
Tg(Isl1-EGFP*)1Slp mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal abducens nerve morphology ( J:213171 )

• approximately 90% penetrance of abducens nerve hypoplasia

abnormal oculomotor nerve morphology ( J:213171 )

• oculomotor nerve superior branch axons terminate prematurely within a bulb with a penetrance of 90%

Allelic Composition	Map1b^tm1Prop/Map1b^tm1Prop Tg(Isl1-EGFP*)1Slp/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map1b^tm1Prop mutation (0 available); any Map1b mutation (85 available)
Tg(Isl1-EGFP*)1Slp mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal oculomotor nerve morphology ( J:213171 )

• 90% of oculomotor nerves have mild proximal thickening in the absence of a bulb, distal thinning, hypoplasia of the oculomotor nerve superior division and a smaller oculomotor nerve inferior division

• about 30% of distal oculomotor nerves have aberrant, long, fasciculated branches that emerge from the oculomotor nerve inferior division exploratory region

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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