Phenotypes associated with this allele

• Allele Symbol: Nr3c1^tm2Ljm
• Allele Name: targeted mutation 2, Louis J Muglia
• Allele ID: MGI:3575536
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nr3c1^tm2Ljm/Nr3c1^tm2Ljm Tg(Camk2a-cre)T50Stl/?	involves: 129 * BALB/c * C57BL/6 * CBA	MGI:3716826
cn2	Nr3c1^tm2Ljm/Nr3c1^tm2Ljm Tg(Lck-cre)548Jxm/?	involves: 129S6/SvEvTac * C57BL/6 * CBA	MGI:3716820

Genotype
MGI:3716826

cn1

• Allelic Composition: Nr3c1^tm2Ljm/Nr3c1^tm2Ljm; Tg(Camk2a-cre)T50Stl/?
• Genetic Background: involves: 129 * BALB/c * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating corticosterone level ( J:96260 )

• peak and basal corticosterone levels are increased at 6 months of age

behavior/neurological

behavioral despair ( J:96260 )

• in forced swim and tail suspension tests mice exhibit a decrease in activity indicative of despair

• however, despair behaviors are reversed by chronic treatment with the tricyclic antidepressant imipramine

decreased locomotor activity ( J:96260 )

• in forced swim and tail suspension tests mice exhibit a decrease in activity indicative of despair

nervous system

absent long-term depression ( J:96260 )

• low-frequency stimulation in the presence of 1um corticosterone of hippocampal slices can not induce long term depression (LTD)

Genotype
MGI:3716820

cn2

• Allelic Composition: Nr3c1^tm2Ljm/Nr3c1^tm2Ljm; Tg(Lck-cre)548Jxm/?
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:97484 )

• mice have increased mortality following treatment with a CD3epsilon antibody

• mortality increases following treatment with staphylococcal enterotoxin A (SEA)

• however, treatment with CD3epsilon antibody or staphylococcal enterotoxin A (SEA) and a COX-2 inhibitor reverses the increase in mortality

immune system

cecum inflammation ( J:97484 )

• treatment with a CD3epsilon antibody leads to inflammation of the cecum

abnormal interferon level ( J:97484 )

• 2 hours after CD3epsilon antibody treatment, interferon-gamma levels are increased

abnormal interleukin level ( J:97484 )

• 8 hours after CD3epsilon antibody treatment, IL-6 levels are increased

abnormal tumor necrosis factor level ( J:97484 )

• 2 hours after CD3epsilon antibody treatment, TNF-alpha levels are increased

increased susceptibility to endotoxin shock ( J:97484 )

• mortality increases following treatment with staphylococcal enterotoxin A (SEA)

digestive/alimentary system

abnormal cecum morphology ( J:97484 )

• treatment with a CD3epsilon antibody leads to increased gastrointestinal damage in the cecum including mucosal and submucosal edema and inflammation along with necrotic regions that are denuded of mucosa

cecum inflammation ( J:97484 )

• treatment with a CD3epsilon antibody leads to inflammation of the cecum

homeostasis/metabolism

abnormal interferon level ( J:97484 )

• 2 hours after CD3epsilon antibody treatment, interferon-gamma levels are increased

abnormal interleukin level ( J:97484 )

• 8 hours after CD3epsilon antibody treatment, IL-6 levels are increased

abnormal tumor necrosis factor level ( J:97484 )

• 2 hours after CD3epsilon antibody treatment, TNF-alpha levels are increased