All Phenotypes Sry<AKR/J> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sry^AKR/J
sex-determining region of Chr Y- AKR/J
MGI:3575651

Summary

14 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Map3k4^tm1Flv/Map3k4⁺ X/Sry^AKR/J	B6.Cg-Map3k4^tm1Flv Chr Y^AKR	MGI:4361432
cx2	X/Sry^AKR/J Sry^RIII	C57BL/6JEi-Chr Y^AKR-Sxr/EiJ	MGI:4839333
cx3	Gadd45g^tm1Jni/Gadd45g⁺ X/Sry^AKR/J	involves: 129P2/OlaHsd * AKR/J * C57BL/6J	MGI:5461496
cx4	Gadd45g^tm1Jni/Gadd45g⁺ X/Sry^AKR/J Tg(Map3k4)#Agre/0	involves: 129P2/OlaHsd * AKR/J * C57BL/6J	MGI:5461497
cx5	Kitl^Sl-18H/Kitl⁺ X/Sry^AKR/J	involves: AKR/J * C57BL/6J	MGI:3778817
cx6	X/Sry^AKR/J Tht/Tht⁺	involves: AKR/J * C57BL/6J	MGI:3778818
cx7	Kit^W-42J/Kit^W-42J X/Sry^AKR/J	involves: AKR/J * C57BL/6J	MGI:3716809
cx8	Kit^W-42J/Kit⁺ X/Sry^AKR/J	involves: AKR/J * C57BL/6J	MGI:3716808
cx9	Kit^W-v/Kit⁺ X/Sry^AKR/J	involves: AKR/J * C57BL/6J	MGI:3778813
cx10	Kit^W-e/Kit⁺ X/Sry^AKR/J	involves: AKR/J * C57BL/6J	MGI:3778814
cx11	Del(10)1H/+ X/Sry^AKR/J	involves: AKR/J * C57BL/6J	MGI:3778816
cx12	Kit^W-19H/Kit⁺ X/Sry^AKR/J	involves: AKR/J * C57BL/6J	MGI:3778792
cx13	Kit^W-27H/Kit⁺ X/Sry^AKR/J	involves: AKR/J * C57BL/6J * CBA/H	MGI:3778815
ot14	X/Sry^AKR/J	AKR/J	MGI:3716806

Allelic Composition	Map3k4^tm1Flv/Map3k4⁺ X/Sry^AKR/J
Genetic Background	B6.Cg-Map3k4^tm1Flv Chr Y^AKR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k4^tm1Flv mutation (1 available); any Map3k4 mutation (78 available)
Sry^AKR/J mutation (6 available); any Sry mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Ovotestis development in Map3k4^tm1Flv/Map3k4⁺ X/Sry^AKR/J embryos, characterised by gonadal poles (brackets) lacking markers of testis development and expressing markers of ovary development

reproductive system

small testis ( J:153050 )

• at 11 weeks

ovotestis ( J:153050 )

primary sex reversal ( J:153050 )

• in XY gonads

endocrine/exocrine glands

small testis ( J:153050 )

• at 11 weeks

Allelic Composition	X/Sry^AKR/J Sry^RIII
Genetic Background	C57BL/6JEi-Chr Y^AKR-Sxr/EiJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sry^AKR/J mutation (6 available); any Sry mutation (54 available)
Sry^RIII mutation (0 available); any Sry mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:127090 )

N	• Background Sensitivity: The presence of the Sxr^RIII from the Tp(Y)1Ct transposition results in normal males with normal embryonic testicular development whereas the C57BL/6JEi-Chr Y consomic mice without the additional Sry have delayed testes cord differentiation

Allelic Composition	Gadd45g^tm1Jni/Gadd45g⁺ X/Sry^AKR/J
Genetic Background	involves: 129P2/OlaHsd * AKR/J * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gadd45g^tm1Jni mutation (0 available); any Gadd45g mutation (11 available)
Sry^AKR/J mutation (6 available); any Sry mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal testis development ( J:191096 )

• severe disruption of testis determination

ovotestis ( J:191096 )

• about 50% of XY mice develop ovotestes with varying degrees of testicular tissue at E14.5

primary sex reversal ( J:191096 )

• about 50% of XY mice develop gonads with ovarian morphology at E14.5

endocrine/exocrine glands

abnormal testis development ( J:191096 )

• severe disruption of testis determination

Allelic Composition	Gadd45g^tm1Jni/Gadd45g⁺ X/Sry^AKR/J Tg(Map3k4)#Agre/0
Genetic Background	involves: 129P2/OlaHsd * AKR/J * C57BL/6J

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:191096 )

N	• testis determination and development in XY mice are similar to wild-type XY controls, unlike in mice not carrying the transgene

Allelic Composition	Kitl^Sl-18H/Kitl⁺ X/Sry^AKR/J
Genetic Background	involves: AKR/J * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kitl^Sl-18H mutation (1 available); any Kitl mutation (94 available)
Sry^AKR/J mutation (6 available); any Sry mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

decreased testis weight ( J:133266 )

• Background Sensitivity: in the presence of Sry^AKR/J on a C57BL/6 background testes weight is less than normal

reproductive system

decreased testis weight ( J:133266 )

• Background Sensitivity: in the presence of Sry^AKR/J on a C57BL/6 background testes weight is less than normal

Allelic Composition	X/Sry^AKR/J Tht/Tht⁺
Genetic Background	involves: AKR/J * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sry^AKR/J mutation (6 available); any Sry mutation (54 available)
Tht mutation (2 available); any Tht mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

decreased testis weight ( J:133266 )

• Background Sensitivity: in the presence of Sry^AKR/J on a C57BL/6 background testes weight is less than normal

reproductive system

decreased testis weight ( J:133266 )

• Background Sensitivity: in the presence of Sry^AKR/J on a C57BL/6 background testes weight is less than normal

Allelic Composition	Kit^W-42J/Kit^W-42J X/Sry^AKR/J
Genetic Background	involves: AKR/J * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W-42J mutation (1 available); any Kit mutation (182 available)
Sry^AKR/J mutation (6 available); any Sry mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:36829 )

• most mice die in utero

reproductive system

abnormal internal male genitalia morphology ( J:36829 )

• 1 male with bilateral testes was born that had minor internal genitalia abnormalities including: right testis is smaller than left, right epididymis' cauda was not completely formed and the average length of the testes was smaller relative to wild-type

Allelic Composition	Kit^W-42J/Kit⁺ X/Sry^AKR/J
Genetic Background	involves: AKR/J * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

small testis ( J:36829 )

• males have right testis smaller than the left, especially when the alleles are inherited from the mother

true hermaphroditism ( J:36829 )

• one hermaphrodite was found with a left testicular gonad and a contralateral putative ovotestis that was associated with both Mullerian and Wolffian duct derivatives

endocrine/exocrine glands

small testis ( J:36829 )

• males have right testis smaller than the left, especially when the alleles are inherited from the mother

Allelic Composition	Kit^W-v/Kit⁺ X/Sry^AKR/J
Genetic Background	involves: AKR/J * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W-v mutation (10 available); any Kit mutation (182 available)
Sry^AKR/J mutation (6 available); any Sry mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

decreased testis weight ( J:133266 )

• Background Sensitivity: in the presence of Sry^AKR/J on a C57BL/6 background testes weight is less than normal

reproductive system

decreased testis weight ( J:133266 )

• Background Sensitivity: in the presence of Sry^AKR/J on a C57BL/6 background testes weight is less than normal

Allelic Composition	Kit^W-e/Kit⁺ X/Sry^AKR/J
Genetic Background	involves: AKR/J * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W-e mutation (2 available); any Kit mutation (182 available)
Sry^AKR/J mutation (6 available); any Sry mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

decreased testis weight ( J:133266 )

• Background Sensitivity: in the presence of Sry^AKR/J on a C57BL/6 background testes weight is less than normal

reproductive system

decreased testis weight ( J:133266 )

• Background Sensitivity: in the presence of Sry^AKR/J on a C57BL/6 background testes weight is less than normal

Allelic Composition	Del(10)1H/+ X/Sry^AKR/J
Genetic Background	involves: AKR/J * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(10)1H mutation (0 available); any Del(10)1H mutation (0 available)
Sry^AKR/J mutation (6 available); any Sry mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

decreased testis weight ( J:133266 )

• Background Sensitivity: in the presence of Sry^AKR/J on a C57BL/6 background testes weight is less than normal

reproductive system

decreased testis weight ( J:133266 )

• Background Sensitivity: in the presence of Sry^AKR/J on a C57BL/6 background testes weight is less than normal

Allelic Composition	Kit^W-19H/Kit⁺ X/Sry^AKR/J
Genetic Background	involves: AKR/J * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W-19H mutation (1 available); any Kit mutation (182 available)
Sry^AKR/J mutation (6 available); any Sry mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

small testis ( J:133266 )

sex reversal ( J:133266 )

• Background Sensitivity: hermaphroditism is found within two generations of backcrossing to C57BL/6 and by the third generation completely sex reversed, sterile XY females are found; the frequency of this sex reversal increases with further backcrossing to C57BL/6

endocrine/exocrine glands

small testis ( J:133266 )

Allelic Composition	Kit^W-27H/Kit⁺ X/Sry^AKR/J
Genetic Background	involves: AKR/J * C57BL/6J * CBA/H

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W-27H mutation (0 available); any Kit mutation (182 available)
Sry^AKR/J mutation (6 available); any Sry mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

decreased testis weight ( J:133266 )

• Background Sensitivity: in the presence of Sry^AKR/J on a C57BL/6 background testes weight is less than normal

reproductive system

decreased testis weight ( J:133266 )

• Background Sensitivity: in the presence of Sry^AKR/J on a C57BL/6 background testes weight is less than normal

Allelic Composition	X/Sry^AKR/J
Genetic Background	AKR/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sry^AKR/J mutation (6 available); any Sry mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:44538 )

N	• despite previous reports, no sex reversal is observed

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