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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Pcp2-EGFP)2Yuza
transgene insertion 2, Michisuke Yuzaki
MGI:3575690
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Itpr1tm1.1Kmik/Itpr1tm1.1Kmik
Tg(Pcp2-cre)2Mpin/0
Tg(Pcp2-EGFP)2Yuza/0 		involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N MGI:5532285
cx2
 		Prex2Gt(RRD186)Byg/Prex2Gt(RRD186)Byg
Tg(Pcp2-EGFP)2Yuza/0 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:3783868


Genotype
MGI:5532285
cn1
Allelic
Composition		 Itpr1tm1.1Kmik/Itpr1tm1.1Kmik
Tg(Pcp2-cre)2Mpin/0
Tg(Pcp2-EGFP)2Yuza/0
Genetic
Background		 involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itpr1tm1.1Kmik mutation (3 available); any Itpr1 mutation (184 available)
Tg(Pcp2-cre)2Mpin mutation (1 available)
Tg(Pcp2-EGFP)2Yuza mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:199800 )
N
• percentage of purkinje fibers synapsing with parallel fibers is normal
abnormal Purkinje cell dendrite morphology ( J:199800 )
• distal spine density is 143% of controls
• spine lengths are greater




Genotype
MGI:3783868
cx2
Allelic
Composition		 Prex2Gt(RRD186)Byg/Prex2Gt(RRD186)Byg
Tg(Pcp2-EGFP)2Yuza/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prex2Gt(RRD186)Byg mutation (0 available); any Prex2 mutation (114 available)
Tg(Pcp2-EGFP)2Yuza mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal Purkinje cell dendrite morphology ( J:133335 )
• the main dendritic trunk appears shriveled and unordered
• the diameter of the main dendrite is reduced by about 20% and the length of the main dendrite tends to be shorter




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory