Analysis Tools
mortality/aging
craniofacial
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• anterior shortening is evident at E14.5 and E15.5
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• variable hypoplasia, accompanied by abnormal curvature
• premature ossification of the early mandible
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• a disproportionate reduction in the size of the anterior body of the mandible is evident at E14.5 and E15.5
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• variable hypoplasia, accompanied by abnormal curvature
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• short and narrow maxilla
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• short and narrow maxilla
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micrognathia
(
J:157112
)
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• short and narrow
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• wide cleft of the secondary palate is seen in nearly all mice when on a congenic FVB/NJ background;
• Background Sensitivity: however, penetrance is decreased after 4 backcrosses onto a C57BL/6J background
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• by E14.5-E15, a specific defect in palate shelf elevation is evident and persists to birth
• when cultured elevation occurs although fusion is variable, suggesting that the in vivo defect is a secondary effect
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• abnormal positioning and morphology of the tongue
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• by E14.5-E15 the tongue remains elevated within the oral cavity
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• shortened and narrowed snout, including the nasal and maxillary bones and nasal cartilage
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narrow snout
(
J:157112
)
short snout
(
J:157112
)
digestive/alimentary system
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• wide cleft of the secondary palate is seen in nearly all mice when on a congenic FVB/NJ background;
• Background Sensitivity: however, penetrance is decreased after 4 backcrosses onto a C57BL/6J background
|
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• by E14.5-E15, a specific defect in palate shelf elevation is evident and persists to birth
• when cultured elevation occurs although fusion is variable, suggesting that the in vivo defect is a secondary effect
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• abnormal positioning and morphology of the tongue
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• by E14.5-E15 the tongue remains elevated within the oral cavity
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• severe hypoplasia
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• severe hypoplasia
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• severe hypoplasia
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• severe
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respiratory system
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• short and narrow
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• histological defects are apparent just before birth (E19.5)
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small lung
(
J:157112
)
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• lungs appear reduced in size compared with wild-type
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• gasping
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growth/size/body
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• short and narrow
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• wide cleft of the secondary palate is seen in nearly all mice when on a congenic FVB/NJ background;
• Background Sensitivity: however, penetrance is decreased after 4 backcrosses onto a C57BL/6J background
|
|
• by E14.5-E15, a specific defect in palate shelf elevation is evident and persists to birth
• when cultured elevation occurs although fusion is variable, suggesting that the in vivo defect is a secondary effect
|
|
• abnormal positioning and morphology of the tongue
|
|
• by E14.5-E15 the tongue remains elevated within the oral cavity
|
|
• shortened and narrowed snout, including the nasal and maxillary bones and nasal cartilage
|
narrow snout
(
J:157112
)
short snout
(
J:157112
)
|
• extremely distended abdomen in which the stomach and intestines become filled with air
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skeleton
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• anterior shortening is evident at E14.5 and E15.5
|
|
• variable hypoplasia, accompanied by abnormal curvature
• premature ossification of the early mandible
|
|
• a disproportionate reduction in the size of the anterior body of the mandible is evident at E14.5 and E15.5
|
|
• variable hypoplasia, accompanied by abnormal curvature
|
|
• short and narrow maxilla
|
|
• short and narrow maxilla
|
micrognathia
(
J:157112
)
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• short and narrow
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• premature ossification of the early mandible
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nervous system
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• severe choroid plexus hypoplasia is evident in the brain ventricle
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endocrine/exocrine glands
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• severe hypoplasia
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• severe hypoplasia
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• severe hypoplasia
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• severe
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vision/eye
retina fold
(
J:157112
)
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• abnormal retinal folds of variable severity are observed in the eye postnatally
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cardiovascular system
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• often exhibiting a cleft at the apex between the ventricles
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• ventricles of the heart appear grossly abnormal and reduced in size
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