All Phenotypes Tg(Agrp-cre)1Gsb MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Agrp-cre)1Gsb
transgene insertion 1, Gregory S Barsh
MGI:3576074

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{tm1(Sirt1)Ktm}/Gt(ROSA)26Sor⁺ Tg(Agrp-cre)1Gsb/0	involves: 129 * C57BL/6J * FVB/N	MGI:5586725
cn2	Gt(ROSA)26Sor^{tm2(Sirt1)Ktm}/Gt(ROSA)26Sor⁺ Tg(Agrp-cre)1Gsb/0	involves: 129 * C57BL/6J * FVB/N	MGI:5586727
cn3	Lepr^tm1.1Chua/Lepr^tm1.1Chua Tg(Agrp-cre)1Gsb/0	involves: 129 * FVB/N	MGI:5526038
cn4	Prkaa2^tm1Vio/Prkaa2^tm1Vio Tg(Agrp-cre)1Gsb/0	involves: 129S2/SvPas * FVB/N	MGI:3817317
cn5	Nhlh2^tm2Thbr/Nhlh2^tm2Thbr Tg(Agrp-cre)1Gsb/0	involves: 129S7/SvEvBrd * C57BL/6 * FVB/N	MGI:5524041
cn6	Gt(ROSA)26Sor^{tm1(Stat3A661CN663C)Sbkv}/Gt(ROSA)26Sor^{tm1(Stat3A661CN663C)Sbkv} Tg(Agrp-cre)1Gsb/?	involves: C57BL/6 * FVB/N	MGI:3779016

Allelic Composition	Gt(ROSA)26Sor^{tm1(Sirt1)Ktm}/Gt(ROSA)26Sor⁺ Tg(Agrp-cre)1Gsb/0
Genetic Background	involves: 129 * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(Sirt1)Ktm} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Agrp-cre)1Gsb mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:209418 )

N	• mice exhibit normal body length • female and male mice fed a high fat high sugar diet exhibit normal body weight

increased body weight ( J:209418 )

• female mice exhibit a tend toward increased body weight

decreased susceptibility to age related obesity ( J:209418 )

• in male mice fed normal chow

behavior/neurological

behavior/neurological phenotype ( J:209418 )

N	• mice fed normal chow or a high fat high sugar diet exhibit normal locomotor activity

decreased food intake ( J:209418 )

• in male mice fed normal chow

increased food intake ( J:209418 )

• in female mice fed normal chow

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:209418 )

N	• mice fed normal chow exhibit normal energy expenditure, plasma T4 levels, fasting-induced lipolysis and rectal temperature • mice fed a high fat high sugar diet exhibit normal energy expenditure and cold tolerance

increased response to leptin ( J:209418 )

• mice exhibit improved leptin sensitivity compared with control mice

adipose tissue

adipose tissue phenotype ( J:209418 )

N	• mice fed normal chow or a high fat high sugar diet exhibit normal adiposity

Allelic Composition	Gt(ROSA)26Sor^{tm2(Sirt1)Ktm}/Gt(ROSA)26Sor⁺ Tg(Agrp-cre)1Gsb/0
Genetic Background	involves: 129 * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm2(Sirt1)Ktm} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Agrp-cre)1Gsb mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

adipose tissue phenotype ( J:209418 )

N	• mice fed normal chow exhibit normal epididymal white adipose tissue weight

behavior/neurological

behavior/neurological phenotype ( J:209418 )

N	• mice fed normal chow exhibit normal food intake and locomotor activity

growth/size/body

growth/size/body region phenotype ( J:209418 )

N	• mice fed normal chow exhibit normal susceptibility to age-associated weight gain and body length

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:209418 )

N	• mice fed normal chow exhibit normal oxygen consumption and rectal temperature

Allelic Composition	Lepr^tm1.1Chua/Lepr^tm1.1Chua Tg(Agrp-cre)1Gsb/0
Genetic Background	involves: 129 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepr^tm1.1Chua mutation (1 available); any Lepr mutation (122 available)
Tg(Agrp-cre)1Gsb mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased liver triglyceride level ( J:199803 )

• blunting of the increase in liver triglycerides during fasting

liver/biliary system

decreased liver triglyceride level ( J:199803 )

• blunting of the increase in liver triglycerides during fasting

Allelic Composition	Prkaa2^tm1Vio/Prkaa2^tm1Vio Tg(Agrp-cre)1Gsb/0
Genetic Background	involves: 129S2/SvPas * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkaa2^tm1Vio mutation (1 available); any Prkaa2 mutation (35 available)
Tg(Agrp-cre)1Gsb mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:123951 )

• at 3 months of age, mice display a mild decrease in body weight compared to wild-type mice

nervous system

abnormal neuron physiology ( J:123951 )

• agouti-related protein expressing neurons are slightly more hyperpolarized than in wild-type mice and do not respond electrophysically to glucose as do wild-type cells

behavior/neurological

enhanced behavioral response to xenobiotic ( J:123951 )

• following treatment with melanotan II, mice exhibit less food intake than similarly treated wild-type

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:123951 )

N	• despite reduction in weight, mice exhibit normal food intake, resting metabolic rate, daily energy expenditure, response to a high fat diet, leptin, glucose and adiponectin levels, and glucose and insulin tolerance

Allelic Composition	Nhlh2^tm2Thbr/Nhlh2^tm2Thbr Tg(Agrp-cre)1Gsb/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nhlh2^tm2Thbr mutation (0 available); any Nhlh2 mutation (13 available)
Tg(Agrp-cre)1Gsb mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:199640 )

N	• mice exhibit normal uteri weight

growth/size/body

growth/size/body region phenotype ( J:199640 )

N	• mice exhibit normal weight

adipose tissue

adipose tissue phenotype ( J:199640 )

N	• mice exhibit normal visceral fat depots

Allelic Composition	Gt(ROSA)26Sor^{tm1(Stat3A661CN663C)Sbkv}/Gt(ROSA)26Sor^{tm1(Stat3A661CN663C)Sbkv} Tg(Agrp-cre)1Gsb/?
Genetic Background	involves: C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(Stat3*A661C*N663C)Sbkv} mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Agrp-cre)1Gsb mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

slow postnatal weight gain ( J:133218 )

• mice on a normal chow diet weigh 10% less than littermate controls from weaning until 20 weeks of age

• differences are more pronounced when mice are kept on a high fat diet with mice weighing 15-20% less until the age of 20 weeks

homeostasis/metabolism

decreased circulating adrenaline level ( J:133218 )

• there is a significant decrease in plasma epinephrine levels in mice fed a normal diet but not in mice fed a high-fat diet

decreased circulating noradrenaline level ( J:133218 )

• there is a significant decrease in plasma norepinephrine levels in mice fed a normal diet but not in mice fed a high-fat diet

increased oxygen consumption ( J:133218 )

• 9 week old mice consume 15-20% more oxygen during both day and night phases

• 13 week old mice consume more than 30% oxygen during the light phase and more than 40% oxygen during the night phase

abnormal glucose homeostasis ( J:133218 )

decreased circulating glucose level ( J:133218 )

• a 16 hour fasts leads to significantly lower blood glucose levels in mice fed a high fat diet compared to controls

decreased circulating insulin level ( J:133218 )

• mice on a high fat diet have slightly less circulating insulin levels

improved glucose tolerance ( J:133218 )

• mice on a high fat diet are significantly more glucose tolerant compared to controls

adipose tissue

decreased gonadal fat pad weight ( J:133218 )

• mice of either sex on a normal chow diet displayed a 30% reduction in epigonodal fat-pad weight at 20 weeks of age

• mice on a high fat diet displayed a 40-60 % weight reduction in the epigonodal fat pads at 20 weeks of age

behavior/neurological

polyphagia ( J:133218 )

• mice exhibit a slight postpubertal hyperphagia

increased locomotor activity ( J:133218 )

• at 9 weeks of age, mice exhibit a dramatic increase in basal locomotor activity with a 40% increase during the light phase and 60% during the dark phase compared to control mice

• mice exhibit the highest locomotor activity at the beginning of the dark cycle where they were more than twice as active as their littermate controls

• there are also greater increases in fasting-induced hyperactivity than in control mice

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