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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cyp27b1tm1Hfd
targeted mutation 1, Hector F DeLuca
MGI:3576226
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cyp27b1tm1Hfd/Cyp27b1tm1Hfd involves: 129S7/SvEvBrd * C57BL/6 MGI:3576368


Genotype
MGI:3576368
hm1
Allelic
Composition		 Cyp27b1tm1Hfd/Cyp27b1tm1Hfd
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyp27b1tm1Hfd mutation (0 available); any Cyp27b1 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
rickets ( J:97370 )
• become rachitic when fed a diet devoid of 1,25-dihydroxyvitamin D3 and phosphorus
• administration of 1,25-dihydroxyvitamin D3 effectively reverses the rachitic condition
• grow, develop, and reproduce normally when maintained on a balanced diet supplemented with 1,25-dihydroxyvitamin D3




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory