Phenotypes associated with this allele

• Allele Symbol: B3gnt2^{Gt(KST308)Byg}
• Allele Name: gene trap KST308, BayGenomics
• Allele ID: MGI:3576265
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	B3gnt2^Gt(KST308)Byg/B3gnt2^Gt(KST308)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:3577332

Genotype
MGI:3577332

hm1

• Allelic Composition: B3gnt2^{Gt(KST308)Byg}/B3gnt2^{Gt(KST308)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

taste/olfaction

taste/olfaction phenotype ( J:97372 )

N • by 2 weeks of age, lactosamine is unexpectedly reexpressed in sensory neurons of homozygous mutant mice through a secondary pathway which is accompanied by the regrowth of axons into the olfactory epithelium glomerular layer and the return of smell perception

abnormal olfactory epithelium morphology ( J:97372 )

• severely disorganized olfactory epithelium innervation and defective glomerular formation during early postnatal period up to 2 weeks

abnormal olfactory receptor morphology ( J:97372 )

• by generating homozygous mutant mice harboring odorant receptor P2(Olfr160^tm2(GFP)Mom), M72 (Olfr17^tm1Mom), and I7 specific reporter genes, authors show axon guidance errors and increased neuronal cell death result in an absence of P2, M72, and I7 glomeruli at P10 of age

abnormal olfaction ( J:97372 )

• between P14 and P28, mutant mice took longer than control littermates to locate hidden food rewards in food-finding tests of olfactory function mice during P14 and P28 of age

nervous system

increased neuron apoptosis ( J:97372 )

• specific subset of odorant receptor-expressing neurons are progressively lost at P10 of age

abnormal olfactory receptor morphology ( J:97372 )

• by generating homozygous mutant mice harboring odorant receptor P2(Olfr160^tm2(GFP)Mom), M72 (Olfr17^tm1Mom), and I7 specific reporter genes, authors show axon guidance errors and increased neuronal cell death result in an absence of P2, M72, and I7 glomeruli at P10 of age

respiratory system

abnormal olfactory epithelium morphology ( J:97372 )

• severely disorganized olfactory epithelium innervation and defective glomerular formation during early postnatal period up to 2 weeks

abnormal olfactory receptor morphology ( J:97372 )

• by generating homozygous mutant mice harboring odorant receptor P2(Olfr160^tm2(GFP)Mom), M72 (Olfr17^tm1Mom), and I7 specific reporter genes, authors show axon guidance errors and increased neuronal cell death result in an absence of P2, M72, and I7 glomeruli at P10 of age

craniofacial

abnormal olfactory epithelium morphology ( J:97372 )

• severely disorganized olfactory epithelium innervation and defective glomerular formation during early postnatal period up to 2 weeks

abnormal olfactory receptor morphology ( J:97372 )

• by generating homozygous mutant mice harboring odorant receptor P2(Olfr160^tm2(GFP)Mom), M72 (Olfr17^tm1Mom), and I7 specific reporter genes, authors show axon guidance errors and increased neuronal cell death result in an absence of P2, M72, and I7 glomeruli at P10 of age

cellular

increased neuron apoptosis ( J:97372 )

• specific subset of odorant receptor-expressing neurons are progressively lost at P10 of age

growth/size/body

abnormal olfactory epithelium morphology ( J:97372 )

• severely disorganized olfactory epithelium innervation and defective glomerular formation during early postnatal period up to 2 weeks

abnormal olfactory receptor morphology ( J:97372 )

• by generating homozygous mutant mice harboring odorant receptor P2(Olfr160^tm2(GFP)Mom), M72 (Olfr17^tm1Mom), and I7 specific reporter genes, authors show axon guidance errors and increased neuronal cell death result in an absence of P2, M72, and I7 glomeruli at P10 of age