Analysis Tools|
Allele Symbol Allele Name Allele ID |
Pla2g15tm1Ytan targeted mutation 1, Yoshio Taniyama MGI:3576269 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no homozygotes showed evidence of atherosclerotic lesions when maintained on regular or atherogenic diet
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• homozygotes fed an atherogenic diet showed a lower increase in total cholesterol levels than seen in controls, particularly in males
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the area of atherosclerotic lesions was significantly increased in the aortas compared to those in homozygous Apoe mutant mice on a normal diet, however cholesterol and triglycerol levels were no different than seen in Apoe mutants
• when fed an atherogenic diet, the extent of atherogenesis was no different from homozygous Apoe mutant mice despite exceptionally high cholesterol levels
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• exceptionally high plasma cholesterol levels when fed an atherogenic diet
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• peritoneal macrophages were more sensitive to apoptosis induced by exposure to oxidized low-density lipoprotein
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• peritoneal macrophages were more sensitive to apoptosis induced by exposure to oxidized low-density lipoprotein
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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