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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Foxp3tm1Flv
targeted mutation 1, Richard A Flavell
MGI:3576270
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Foxp3tm1Flv/Foxp3+ involves: C57BL/6 MGI:3576692
cn2
 		Foxp3tm1Flv/Foxp3+
B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv
Tg(Cd4-cre)1Cwi/? 		involves: 129S6/SvEvTac * C57BL/6 * DBA/2 MGI:3720254


Genotype
MGI:3576692
ht1
Allelic
Composition		 Foxp3tm1Flv/Foxp3+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm1Flv mutation (3 available); any Foxp3 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:97415 )
• heterozygotes are fertile, develop normally, and have normal lymphocyte development and function




Genotype
MGI:3720254
cn2
Allelic
Composition		 Foxp3tm1Flv/Foxp3+
B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv
Tg(Cd4-cre)1Cwi/?
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B9d2/Tgfb1tm1Flv mutation (0 available); any Tgfb1 mutation (35 available)
Foxp3tm1Flv mutation (3 available); any Foxp3 mutation (58 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
Tgfb1tm2Flv mutation (0 available); any Tgfb1 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased regulatory T cell number ( J:123547 )
• Foxp3+ regulatory T cells are increased 2-fold relative to wild-type mice
• the numbers of regulatory T cells is increased in the peripheral and mesenteric lymph nodes, spleens and among the lamina propria mononuclear cell infiltrate of the colon
• proliferation of Foxp3+ cells and CD4+CD8+Foxp3- cells is increased in association with the development of colitis

hematopoietic system
increased regulatory T cell number ( J:123547 )
• Foxp3+ regulatory T cells are increased 2-fold relative to wild-type mice
• the numbers of regulatory T cells is increased in the peripheral and mesenteric lymph nodes, spleens and among the lamina propria mononuclear cell infiltrate of the colon
• proliferation of Foxp3+ cells and CD4+CD8+Foxp3- cells is increased in association with the development of colitis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory