normal phenotype
• heterozygotes are fertile, develop normally, and have normal lymphocyte development and function
|
Allele Symbol Allele Name Allele ID |
Foxp3tm1Flv targeted mutation 1, Richard A Flavell MGI:3576270 |
||||||||||||
Summary |
2 genotypes
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• heterozygotes are fertile, develop normally, and have normal lymphocyte development and function
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• Foxp3+ regulatory T cells are increased 2-fold relative to wild-type mice
• the numbers of regulatory T cells is increased in the peripheral and mesenteric lymph nodes, spleens and among the lamina propria mononuclear cell infiltrate of the colon
• proliferation of Foxp3+ cells and CD4+CD8+Foxp3- cells is increased in association with the development of colitis
|
• Foxp3+ regulatory T cells are increased 2-fold relative to wild-type mice
• the numbers of regulatory T cells is increased in the peripheral and mesenteric lymph nodes, spleens and among the lamina propria mononuclear cell infiltrate of the colon
• proliferation of Foxp3+ cells and CD4+CD8+Foxp3- cells is increased in association with the development of colitis
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 11/05/2024 MGI 6.24 |
|
|