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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Ins2*Y16A)3Ell
transgene insertion 3, John F Elliot
MGI:3576273
Summary 4 genotypes


Genotype
MGI:3619054
cx1
Allelic
Composition		 Ins1tm1Jja/Ins1tm1Jja
Ins2tm1Jja/Ins2tm1Jja
Tg(Ins2*Y16A)3Ell/0
Genetic
Background		 NOD.Cg-Ins1tm1Jja Ins2tm1Jja Tg(Ins2*Y16A)3Ell
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ins1tm1Jja mutation (5 available); any Ins1 mutation (46 available)
Ins2tm1Jja mutation (4 available); any Ins2 mutation (93 available)
Tg(Ins2*Y16A)3Ell mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
salivary gland inflammation ( J:98583 )
• at 26 weeks of age, sialitis is observed but not insulitis
decreased susceptibility to autoimmune diabetes ( J:98583 )
• no female double knockout mice carrying the transgene on a NOD background develop diabetes over 30 weeks of observation
decreased anti-insulin autoantibody level ( J:98583 )
• females lacking both insulin genes do not produce insulin autoantibodies

digestive/alimentary system
salivary gland inflammation ( J:98583 )
• at 26 weeks of age, sialitis is observed but not insulitis

endocrine/exocrine glands
salivary gland inflammation ( J:98583 )
• at 26 weeks of age, sialitis is observed but not insulitis

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
NOT type 1 diabetes mellitus DOID:9744 OMIM:222100
 J:98583




Genotype
MGI:3619055
cx2
Allelic
Composition		 Ins1tm1Jja/Ins1tm1Jja
Tg(Ins2*Y16A)3Ell/0
Genetic
Background		 NOD.Cg-Ins1tm1Jja Tg(Ins2*Y16A)3Ell
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ins1tm1Jja mutation (5 available); any Ins1 mutation (46 available)
Tg(Ins2*Y16A)3Ell mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
autoimmune response ( J:98583 )
• female transgenic mice lacking the Ins2 gene do not show any increased resistance to diabetes compared to nontransgenic mice lacking the gene




Genotype
MGI:3619056
cx3
Allelic
Composition		 Ins2tm1Jja/Ins2tm1Jja
Tg(Ins2*Y16A)3Ell/0
Genetic
Background		 NOD.Cg-Ins2tm1Jja Tg(Ins2*Y16A)3Ell
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ins2tm1Jja mutation (4 available); any Ins2 mutation (93 available)
Tg(Ins2*Y16A)3Ell mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
autoimmune response ( J:98583 )
• transgenic female mice lacking the Ins2 gene do not show increased resistance to diabetes development compared to nontransgenic NOD animals lacking the gene
increased anti-insulin autoantibody level ( J:98583 )
• female mice having the insulin 1 gene but lacking the insulin 2 gene produce insulin autoantibodies




Genotype
MGI:3619409
tg4
Allelic
Composition		 Tg(Ins2*Y16A)3Ell/0
Genetic
Background		 NOD-Tg(Ins2*Y16A)3Ell
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ins2*Y16A)3Ell mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to autoimmune diabetes ( J:98583 )
• 15% of female mice carrying this transgene develop diabetes in the presence of native insulin genes by 35 weeks of age

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
 J:98583




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory