Phenotypes associated with this allele

• Allele Symbol: Tnfsf4^{Ath1-PERA/EiJ}
• Allele Name: PERA/EiJ
• Allele ID: MGI:3576370
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnfsf4^Ath1-PERA/EiJ/Tnfsf4^Ath1-PERA/EiJ	B6.PERA-Tnfsf4^Ath1-PERA/EiJ/Pgn	MGI:3576512
ht2	Tnfsf4^Ath1-PERA/EiJ/Tnfsf4^Ath1-C57BL/6J	B6.PERA-Tnfsf4^Ath1-PERA/EiJ/Pgn	MGI:3576511

Genotype
MGI:3576512

hm1

• Allelic Composition: Tnfsf4^{Ath1-PERA/EiJ}/Tnfsf4^{Ath1-PERA/EiJ}
• Genetic Background: B6.PERA-Tnfsf4^{Ath1-PERA/EiJ}/Pgn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating HDL cholesterol level ( J:79722 )

• HDL cholesterol levels are higher in mice homozygous for the PERA/EiJ allele than in homozygotes for the C57BL/6J allele

• homozygotes for the PERA allele maintain high HDL cholesterol levels when fed a high-fat diet

cardiovascular system

abnormal blood vessel morphology ( J:79722 )

• homozygous mice develop smaller aortic fatty streaks than do C57BL/6J control mice when fed a high-fat diet

Genotype
MGI:3576511

ht2

• Allelic Composition: Tnfsf4^{Ath1-PERA/EiJ}/Tnfsf4^{Ath1-C57BL/6J}
• Genetic Background: B6.PERA-Tnfsf4^{Ath1-PERA/EiJ}/Pgn

homeostasis/metabolism

increased circulating HDL cholesterol level ( J:79722 )

• mice heterozygous for the PERA/EiJ allele exhibit higher HDL cholesterol levels than do those homozygous for the C57BL/6J allele