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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tnfsf4Ath1-PERA/EiJ
PERA/EiJ
MGI:3576370
Summary 2 genotypes


Genotype
MGI:3576512
hm1
Allelic
Composition		 Tnfsf4Ath1-PERA/EiJ/Tnfsf4Ath1-PERA/EiJ
Genetic
Background		 B6.PERA-Tnfsf4Ath1-PERA/EiJ/Pgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf4Ath1-PERA/EiJ mutation (1 available); any Tnfsf4 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating HDL cholesterol level ( J:79722 )
• HDL cholesterol levels are higher in mice homozygous for the PERA/EiJ allele than in homozygotes for the C57BL/6J allele
• homozygotes for the PERA allele maintain high HDL cholesterol levels when fed a high-fat diet

cardiovascular system
abnormal blood vessel morphology ( J:79722 )
• homozygous mice develop smaller aortic fatty streaks than do C57BL/6J control mice when fed a high-fat diet




Genotype
MGI:3576511
ht2
Allelic
Composition		 Tnfsf4Ath1-PERA/EiJ/Tnfsf4Ath1-C57BL/6J
Genetic
Background		 B6.PERA-Tnfsf4Ath1-PERA/EiJ/Pgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf4Ath1-C57BL/6J mutation (0 available); any Tnfsf4 mutation (33 available)
Tnfsf4Ath1-PERA/EiJ mutation (1 available); any Tnfsf4 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating HDL cholesterol level ( J:79722 )
• mice heterozygous for the PERA/EiJ allele exhibit higher HDL cholesterol levels than do those homozygous for the C57BL/6J allele




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory