Phenotypes associated with this allele

• Allele Symbol: Gata6^tm1Sad
• Allele Name: targeted mutation 1, Stephen A Duncan
• Allele ID: MGI:3576383
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gata6^tm1Sad/Gata6^tm1Sad	involves: 129S1/Sv * 129X1/SvJ	MGI:3576513

Genotype
MGI:3576513

hm1

• Allelic Composition: Gata6^tm1Sad/Gata6^tm1Sad
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:97579 )

• tetraploid rescued ES cell derived homozygous embryos die around E10.5

liver/biliary system

abnormal liver bud morphology ( J:97579 )

• in tetraploid rescued ES cell derived homozygous embryos, the liver bud forms but fails to expand by E10.5 and at E10.5 the liver bud is virtually indiscernible indicating a failure of the hepatoblasts to delaminate from the foregut

• however as in controls, the septum transversum mesenchyme surrounds the hepatic bud

embryo

decreased embryo size ( J:97579 )

• tetraploid rescued ES cell derived homozygous embryos are smaller than control embryos but develop at the same rate

cardiovascular system

cardiovascular system phenotype ( J:97579 )

N • in tetraploid rescued ES cell derived homozygous embryos, at E9.5, cardiogenesis and endothelial cell development are normal

growth/size/body

decreased embryo size ( J:97579 )

• tetraploid rescued ES cell derived homozygous embryos are smaller than control embryos but develop at the same rate