About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Irf5tm1Ttg
targeted mutation 1, Tadatsugu Taniguchi
MGI:3576384
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Irf5tm1Ttg/Irf5tm1Ttg B6.129P2-Irf5tm1Ttg MGI:5319392
hm2
 		Irf5tm1Ttg/Irf5tm1Ttg involves: 129P2/OlaHsd * C57BL/6 MGI:3576636
cx3
 		Dock2m1Hsd/Dock2m1Hsd
Irf5tm1Ttg/Irf5tm1Ttg 		B6NHsd.Cg-Irf5tm1Ttg Dock2m1Hsd MGI:5319391


Genotype
MGI:5319392
hm1
Allelic
Composition		 Irf5tm1Ttg/Irf5tm1Ttg
Genetic
Background		 B6.129P2-Irf5tm1Ttg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf5tm1Ttg mutation (0 available); any Irf5 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:182658 )
N
• mice exhibit normal B cell and plasmacytoid dendritic cell development and IFNalpha production following CpG-A stimulation of dendritic cells
decreased interferon-alpha secretion ( J:182658 )
• 1.3-fold in splenocytes infected with HSV-1
decreased interleukin-6 secretion ( J:182658 )
• 2.0- to 2.4-fold in splenocytes infected with HSV-1
decreased tumor necrosis factor secretion ( J:182658 )
• from plasmacytoid dendritic cell stimulated with CpG-B or imiquimod
• 5.6- to 7.1-fold in splenocytes infected with HSV-1
abnormal response to infection ( J:182658 )
• splenocytes infected with HSV-1 exhibit reduced production of IL6 (2.0- to 2.4-fold), TNF (5.6- to 7.1-fold) and IFNa (1.3-fold) compared with wild-type cells
• mice infected with West Nile virus exhibit a 2.6-fold reduction in anti-WNV IgG2c compared with wild-type mice




Genotype
MGI:3576636
hm2
Allelic
Composition		 Irf5tm1Ttg/Irf5tm1Ttg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf5tm1Ttg mutation (0 available); any Irf5 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:182658 )
N
• mice exhibit normal B cell and plasmacytoid dendritic cell development
abnormal T-helper 1 physiology ( J:97567 )
• exhibit a deficiency in the Th1 immune response
decreased circulating interleukin-12b level ( J:97567 )
• decrease in serum levels of IL-12p40 in response to LPS or umethylated DNA treatment
decreased circulating interleukin-6 level ( J:97567 )
• decrease in serum levels of IL-6 in response to LPS or umethylated DNA treatment
decreased circulating tumor necrosis factor level ( J:97567 )
• decrease in serum levels of TNF-alpha in response to LPS or umethylated DNA treatment
decreased susceptibility to bacterial infection ( J:97567 )
• resistance to lipopolysaccharide (LPS) and unmethylated DNA (CpG-B) induced endotoxic shock

homeostasis/metabolism
decreased circulating interleukin-12b level ( J:97567 )
• decrease in serum levels of IL-12p40 in response to LPS or umethylated DNA treatment
decreased circulating interleukin-6 level ( J:97567 )
• decrease in serum levels of IL-6 in response to LPS or umethylated DNA treatment
decreased circulating tumor necrosis factor level ( J:97567 )
• decrease in serum levels of TNF-alpha in response to LPS or umethylated DNA treatment

hematopoietic system
abnormal T-helper 1 physiology ( J:97567 )
• exhibit a deficiency in the Th1 immune response




Genotype
MGI:5319391
cx3
Allelic
Composition		 Dock2m1Hsd/Dock2m1Hsd
Irf5tm1Ttg/Irf5tm1Ttg
Genetic
Background		 B6NHsd.Cg-Irf5tm1Ttg Dock2m1Hsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock2m1Hsd mutation (0 available); any Dock2 mutation (143 available)
Irf5tm1Ttg mutation (0 available); any Irf5 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:182658 )
• mice exhibit impaired B cell and plasmacytoid dendritic cell development compared with wild-type mice
• however, expression of Dock2 rescues B cell and plasmacytoid dendritic cell development
decreased plasmacytoid dendritic cell number ( J:182658 )
• sharp reduction in the spleen (8.7-fold) and blood (6.2-fold)
• reduced percentage to total leukocytes in the peripheral blood
increased plasmacytoid dendritic cell number ( J:182658 )
• slight increase in frequency and number in the bone marrow
absent marginal zone B cells ( J:182658 )
• virtually absent
increased B cell number ( J:182658 )
• in the blood
decreased splenocyte number ( J:182658 )
• frequency (3.1-fold) and number (1.3-fold) at 8 weeks
decreased interferon-alpha secretion ( J:182658 )
• from plasmacytoid dendritic cell stimulated with CpG-A
abnormal response to infection ( J:182658 )
• mice exhibit reduced (7-fold at day 6 and 43-fold at day 9) specific IgG titers compared with wild-type mice

hematopoietic system
abnormal B cell differentiation ( J:182658 )
• mice exhibit impaired B cell and plasmacytoid dendritic cell development compared with wild-type mice
• however, expression of Dock2 rescues B cell and plasmacytoid dendritic cell development
decreased plasmacytoid dendritic cell number ( J:182658 )
• sharp reduction in the spleen (8.7-fold) and blood (6.2-fold)
• reduced percentage to total leukocytes in the peripheral blood
increased plasmacytoid dendritic cell number ( J:182658 )
• slight increase in frequency and number in the bone marrow
absent marginal zone B cells ( J:182658 )
• virtually absent
increased B cell number ( J:182658 )
• in the blood
decreased splenocyte number ( J:182658 )
• frequency (3.1-fold) and number (1.3-fold) at 8 weeks




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory