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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Irf5tm1Ttg
targeted mutation 1, Tadatsugu Taniguchi
MGI:3576384
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Irf5tm1Ttg/Irf5tm1Ttg B6.129P2-Irf5tm1Ttg MGI:5319392
hm2
 		Irf5tm1Ttg/Irf5tm1Ttg involves: 129P2/OlaHsd * C57BL/6 MGI:3576636
cx3
 		Dock2m1Hsd/Dock2m1Hsd
Irf5tm1Ttg/Irf5tm1Ttg 		B6NHsd.Cg-Irf5tm1Ttg Dock2m1Hsd MGI:5319391


Genotype
MGI:5319392
hm1
Allelic
Composition		 Irf5tm1Ttg/Irf5tm1Ttg
Genetic
Background		 B6.129P2-Irf5tm1Ttg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf5tm1Ttg mutation (0 available); any Irf5 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:182658 )
N
• mice exhibit normal B cell and plasmacytoid dendritic cell development and IFNalpha production following CpG-A stimulation of dendritic cells
decreased interferon-alpha secretion ( J:182658 )
• 1.3-fold in splenocytes infected with HSV-1
decreased interleukin-6 secretion ( J:182658 )
• 2.0- to 2.4-fold in splenocytes infected with HSV-1
decreased tumor necrosis factor secretion ( J:182658 )
• from plasmacytoid dendritic cell stimulated with CpG-B or imiquimod
• 5.6- to 7.1-fold in splenocytes infected with HSV-1
abnormal response to infection ( J:182658 )
• splenocytes infected with HSV-1 exhibit reduced production of IL6 (2.0- to 2.4-fold), TNF (5.6- to 7.1-fold) and IFNa (1.3-fold) compared with wild-type cells
• mice infected with West Nile virus exhibit a 2.6-fold reduction in anti-WNV IgG2c compared with wild-type mice




Genotype
MGI:3576636
hm2
Allelic
Composition		 Irf5tm1Ttg/Irf5tm1Ttg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf5tm1Ttg mutation (0 available); any Irf5 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:182658 )
N
• mice exhibit normal B cell and plasmacytoid dendritic cell development
abnormal T-helper 1 physiology ( J:97567 )
• exhibit a deficiency in the Th1 immune response
decreased circulating interleukin-12b level ( J:97567 )
• decrease in serum levels of IL-12p40 in response to LPS or umethylated DNA treatment
decreased circulating interleukin-6 level ( J:97567 )
• decrease in serum levels of IL-6 in response to LPS or umethylated DNA treatment
decreased circulating tumor necrosis factor level ( J:97567 )
• decrease in serum levels of TNF-alpha in response to LPS or umethylated DNA treatment
decreased susceptibility to bacterial infection ( J:97567 )
• resistance to lipopolysaccharide (LPS) and unmethylated DNA (CpG-B) induced endotoxic shock

homeostasis/metabolism
decreased circulating interleukin-12b level ( J:97567 )
• decrease in serum levels of IL-12p40 in response to LPS or umethylated DNA treatment
decreased circulating interleukin-6 level ( J:97567 )
• decrease in serum levels of IL-6 in response to LPS or umethylated DNA treatment
decreased circulating tumor necrosis factor level ( J:97567 )
• decrease in serum levels of TNF-alpha in response to LPS or umethylated DNA treatment

hematopoietic system
abnormal T-helper 1 physiology ( J:97567 )
• exhibit a deficiency in the Th1 immune response




Genotype
MGI:5319391
cx3
Allelic
Composition		 Dock2m1Hsd/Dock2m1Hsd
Irf5tm1Ttg/Irf5tm1Ttg
Genetic
Background		 B6NHsd.Cg-Irf5tm1Ttg Dock2m1Hsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock2m1Hsd mutation (0 available); any Dock2 mutation (143 available)
Irf5tm1Ttg mutation (0 available); any Irf5 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:182658 )
• mice exhibit impaired B cell and plasmacytoid dendritic cell development compared with wild-type mice
• however, expression of Dock2 rescues B cell and plasmacytoid dendritic cell development
decreased plasmacytoid dendritic cell number ( J:182658 )
• sharp reduction in the spleen (8.7-fold) and blood (6.2-fold)
• reduced percentage to total leukocytes in the peripheral blood
increased plasmacytoid dendritic cell number ( J:182658 )
• slight increase in frequency and number in the bone marrow
absent marginal zone B cells ( J:182658 )
• virtually absent
increased B cell number ( J:182658 )
• in the blood
decreased splenocyte number ( J:182658 )
• frequency (3.1-fold) and number (1.3-fold) at 8 weeks
decreased interferon-alpha secretion ( J:182658 )
• from plasmacytoid dendritic cell stimulated with CpG-A
abnormal response to infection ( J:182658 )
• mice exhibit reduced (7-fold at day 6 and 43-fold at day 9) specific IgG titers compared with wild-type mice

hematopoietic system
abnormal B cell differentiation ( J:182658 )
• mice exhibit impaired B cell and plasmacytoid dendritic cell development compared with wild-type mice
• however, expression of Dock2 rescues B cell and plasmacytoid dendritic cell development
decreased plasmacytoid dendritic cell number ( J:182658 )
• sharp reduction in the spleen (8.7-fold) and blood (6.2-fold)
• reduced percentage to total leukocytes in the peripheral blood
increased plasmacytoid dendritic cell number ( J:182658 )
• slight increase in frequency and number in the bone marrow
absent marginal zone B cells ( J:182658 )
• virtually absent
increased B cell number ( J:182658 )
• in the blood
decreased splenocyte number ( J:182658 )
• frequency (3.1-fold) and number (1.3-fold) at 8 weeks




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory