Phenotypes associated with this allele

• Allele Symbol: Gab2^tm1Pngr
• Allele Name: targeted mutation 1, Josef M Penninger
• Allele ID: MGI:3576606
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gab2^tm1Pngr/Gab2^tm1Pngr	B6.Cg-Gab2^tm1Pngr	MGI:3576670

Genotype
MGI:3576670

hm1

• Allelic Composition: Gab2^tm1Pngr/Gab2^tm1Pngr
• Genetic Background: B6.Cg-Gab2^tm1Pngr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal osteoclast morphology ( J:97515 )

• the osteoclast surface to bone surface ratio, and osteoclast number to bone surface ratio are reduced in long bones

abnormal osteoclast differentiation ( J:97515 )

• osteoclast formation is impaired in vitro

• however, osteoblast numbers and formation are normal

decreased osteoclast cell number ( J:97515 )

• the number of osteoclasts is reduced in long bones

increased bone mass ( J:97515 )

• bone mass is also increased in the spine

increased compact bone mass ( J:97515 )

• cortical bone mass is increased in the long bones

increased trabecular bone mass ( J:97515 )

• trabecular bone mass is increased in the long bones

osteopetrosis ( J:97515 )

decreased bone resorption ( J:97515 )

• bone turnover by osteoclasts is reduced

hematopoietic system

decreased bone marrow cell number ( J:97515 )

• cellularity of the bone marrow is decreased; however, cell numbers and lymphocyte populations in the thymus, peripheral blood, lymph nodes, and spleen are all normal

abnormal osteoclast morphology ( J:97515 )

• the osteoclast surface to bone surface ratio, and osteoclast number to bone surface ratio are reduced in long bones

abnormal osteoclast differentiation ( J:97515 )

• osteoclast formation is impaired in vitro

• however, osteoblast numbers and formation are normal

decreased osteoclast cell number ( J:97515 )

• the number of osteoclasts is reduced in long bones

immune system

abnormal osteoclast morphology ( J:97515 )

• the osteoclast surface to bone surface ratio, and osteoclast number to bone surface ratio are reduced in long bones

abnormal osteoclast differentiation ( J:97515 )

• osteoclast formation is impaired in vitro

• however, osteoblast numbers and formation are normal

decreased osteoclast cell number ( J:97515 )

• the number of osteoclasts is reduced in long bones

cellular

abnormal osteoclast differentiation ( J:97515 )

• osteoclast formation is impaired in vitro

• however, osteoblast numbers and formation are normal