All Phenotypes Ano5<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ano5⁺
wild type
MGI:3576660

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ano5^em1Huyi/Ano5⁺	C57BL/6N-Ano5^em1Huyi	MGI:6489971

Allelic Composition	Ano5^em1Huyi/Ano5⁺
Genetic Background	C57BL/6N-Ano5^em1Huyi

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ano5^em1Huyi mutation (0 available); any Ano5 mutation (67 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal osteoblast physiology ( J:294237 )

• osteoblast cultures develop more mineral nodule deposition in osteogenic medium than wild-type cultures but less than in homozygous cultures, indicating intermediate levels of mineralization

abnormal skeleton morphology ( J:294237 )

• mice are phenotypically similar to homozygous mice and exhibit gnathodiaphyseal dysplasia-like skeletal phenotypes with age

homeostasis/metabolism

increased circulating alkaline phosphatase level ( J:294237 )

• serum alkaline phosphatase levels are increased by approximately 23% at 12 weeks of age

cellular

abnormal osteoblast physiology ( J:294237 )

• osteoblast cultures develop more mineral nodule deposition in osteogenic medium than wild-type cultures but less than in homozygous cultures, indicating intermediate levels of mineralization

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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