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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Vegfdtm1Mach
targeted mutation 1, Marc G Achen
MGI:3576785
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Vegfdtm1Mach/Vegfdtm1Mach involves: 129S1/Sv MGI:3577313
cx2
 		Vegfdtm1Mach/Vegfdtm1Mach
Vegfctm1Ali/Vegfctm1Ali 		involves: 129S1/Sv * 129X1/SvJ MGI:3805196
ot3
 		Vegfdtm1Mach/Y involves: 129S1/Sv MGI:3577605


Genotype
MGI:3577313
hm1
Allelic
Composition		 Vegfdtm1Mach/Vegfdtm1Mach
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vegfdtm1Mach mutation (2 available); any Vegfd mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:97571 )
• homozygous females are morphologically normal, can suckle, and have grossly normal lymphatic system morphology and function




Genotype
MGI:3805196
cx2
Allelic
Composition		 Vegfdtm1Mach/Vegfdtm1Mach
Vegfctm1Ali/Vegfctm1Ali
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vegfctm1Ali mutation (1 available); any Vegfc mutation (28 available)
Vegfdtm1Mach mutation (2 available); any Vegfd mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal lymphatic vessel morphology ( J:137909 )
• lymph sacs are absent at E13.5
abnormal lymphangiogenesis ( J:137909 )
• sprouting of lymphatic endothelial cells from the jugular vein is arrested at E13.5

cardiovascular system
cardiovascular system phenotype ( J:137909 )
N
• unlike mice homozygous for Flt4tm1Ali, blood vessel morphology is similar to wild-type at E11.5

mortality/aging




Genotype
MGI:3577605
ot3
Allelic
Composition		 Vegfdtm1Mach/Y
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vegfdtm1Mach mutation (2 available); any Vegfd mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:97571 )
• hemizygous males are morphologically normal, can suckle, and have grossly normal lymphatic system morphology and function




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory