About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adamts5tm1.1Eam
targeted mutation 1.1, Elisabeth A Morris
MGI:3576786
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Adamts5tm1.1Eam/Adamts5tm1.1Eam involves: 129S5/SvEvBrd MGI:3577950
ht2
 		Adamts5tm1.1Eam/Adamts5+ involves: 129S5/SvEvBrd MGI:3577954


Genotype
MGI:3577950
hm1
Allelic
Composition		 Adamts5tm1.1Eam/Adamts5tm1.1Eam
Genetic
Background		 involves: 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts5tm1.1Eam mutation (0 available); any Adamts5 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to induced arthritis ( J:97590 )
• after surgically induced joint instability (to induce osteoarthritis), saw a significant reduction in the severity of cartilage destruction

skeleton
decreased susceptibility to induced arthritis ( J:97590 )
• after surgically induced joint instability (to induce osteoarthritis), saw a significant reduction in the severity of cartilage destruction




Genotype
MGI:3577954
ht2
Allelic
Composition		 Adamts5tm1.1Eam/Adamts5+
Genetic
Background		 involves: 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts5tm1.1Eam mutation (0 available); any Adamts5 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to induced arthritis ( J:97590 )
• severity of osteoarthritis was significantly reduced 8 weeks after induction of joint instability

skeleton
decreased susceptibility to induced arthritis ( J:97590 )
• severity of osteoarthritis was significantly reduced 8 weeks after induction of joint instability




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory