Analysis Tools|
Allele Symbol Allele Name Allele ID |
Drd2tm1Mok targeted mutation 1, Motoya Katsuki MGI:3576789 |
||||||||||||
| Summary |
2 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• the dopamine inhibition concentration-response curve for inhibitory postsynaptic currents of globus pallidus neurons is monophasic unlike the curve for wild-type mice which is biphasic
• dopamine has no effect on the paired-pulse ratio of inhibitory postsynaptic currents of globus pallidus neurons in mutants unlike in wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• the intermediate lobe is enlarged; however the anterior lobe is normal
|
|
• in mutant neurons from the substantia nigra compacta 100 um dopamine had no effect on membrane potentials unlike in wild-type neurons where dopamine inhibited spontaneous firing
|
|
• agouti coat color is darker with the back darker than other regions of the body
|
|
• the intermediate lobe is enlarged; however the anterior lobe is normal
|
|
• alpha-melanocyte stimulating hormone levels are elevated about 15-fold compared to wild-type mice
|
|
• levels of pro-opiomelanocortin are increased in the pituitary; however, levels of prolactin are normal
|
|
• agouti coat color is darker with the back darker than other regions of the body
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 12/10/2024 MGI 6.24 |
|
|
|
||
