Phenotypes associated with this allele

• Allele Symbol: Cartpt^tm1Hmh
• Allele Name: targeted mutation 1, Hansen M Hsiung
• Allele ID: MGI:3576858
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cartpt^tm1Hmh/Cartpt^tm1Hmh	involves: 129P2/OlaHsd * C57BL/6	MGI:3578776
hm2	Cartpt^tm1Hmh/Cartpt^tm1Hmh	Not Specified	MGI:3579024
ht3	Cartpt^tm1Hmh/Cartpt^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3578777

Genotype
MGI:3578776

hm1

• Allelic Composition: Cartpt^tm1Hmh/Cartpt^tm1Hmh
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:97913 )

• significant increase in body weight when fed a high-fat diet, but not a regular chow diet, compared to controls

adipose tissue

increased total body fat amount ( J:97913 )

• when fed a high-fat diet, exhibited significantly higher fat mass beginning at the 8th week in males and after the 15th week in females

behavior/neurological

abnormal food intake ( J:97913 )

• exhibited increased weekly food consumption when fed a high-fat diet compared to wildtype

growth/size/body

increased susceptibility to diet-induced obesity ( J:97913 )

• significant increase in body weight when fed a high-fat diet, but not a regular chow diet, compared to controls

Genotype
MGI:3579024

hm2

• Allelic Composition: Cartpt^tm1Hmh/Cartpt^tm1Hmh
• Genetic Background: Not Specified

skeleton

abnormal osteoclast morphology ( J:97566 )

• osteoclast surface and number was doubled in homozygous mutant osteoclasts

• however, osteoblast numbers and bone formation rates were normal

increased osteoclast cell number ( J:97566 )

decreased bone mass ( J:97566 )

• exhibit low bone mass at 6 months of age

• leptin intracerebroventricular infusion decreased bone mass and osteoclast surface more efficiently than in wildtype

hematopoietic system

abnormal osteoclast morphology ( J:97566 )

• osteoclast surface and number was doubled in homozygous mutant osteoclasts

• however, osteoblast numbers and bone formation rates were normal

increased osteoclast cell number ( J:97566 )

immune system

abnormal osteoclast morphology ( J:97566 )

• osteoclast surface and number was doubled in homozygous mutant osteoclasts

• however, osteoblast numbers and bone formation rates were normal

increased osteoclast cell number ( J:97566 )

Genotype
MGI:3578777

ht3

• Allelic Composition: Cartpt^tm1Hmh/Cartpt⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:97913 )

• females, but not males, exhibited a significant increase in body weight when fed a high-fat diet, but not on a regular diet, compared to controls

adipose tissue

increased total body fat amount ( J:97913 )

• females exhibited significantly higher fat mass when fed a high-fat diet

behavior/neurological

abnormal food intake ( J:97913 )

• females, but not males, exhibited increased weekly food consumption when fed a high-fat diet compared to wildtype

• males exhibited decreased weekly food consumption when fed a high-fat diet compared to wildtype

growth/size/body

increased susceptibility to diet-induced obesity ( J:97913 )

• females, but not males, exhibited a significant increase in body weight when fed a high-fat diet, but not on a regular diet, compared to controls