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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Morf4l1tm1Kto
targeted mutation 1, Kaoru Tominaga
MGI:3576922
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Morf4l1tm1Kto/Morf4l1tm1Kto involves: 129S7/SvEvBrd MGI:3577651
hm2
 		Morf4l1tm1Kto/Morf4l1tm1Kto involves: 129S7/SvEvBrd * C57BL/6J MGI:3582502
cx3
 		Morf4l1tm1Kto/Morf4l1tm1Kto
Morf4l2tm1.1Kto/Morf4l2tm1.1Kto 		involves: 129S7/SvEvBrd * C57BL/6J MGI:3582501
cx4
 		Morf4l1tm1Kto/Morf4l1tm1Kto
Morf4l2tm1.1Kto/Y 		involves: 129S7/SvEvBrd * C57BL/6J MGI:3582503


Genotype
MGI:3577651
hm1
Allelic
Composition		 Morf4l1tm1Kto/Morf4l1tm1Kto
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Morf4l1tm1Kto mutation (0 available); any Morf4l1 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:97640 )
• only 6.7% of pups at birth are homozygous and these die shortly after birth; however the expected number of homozygous embryos are found at E14.5

muscle

respiratory system
abnormal pulmonary alveolus morphology ( J:97640 )
• alveolar space is significantly reduced in neonates
respiratory failure ( J:97640 )
• the lungs do not appear to inflate after birth

cardiovascular system
visceral vascular congestion ( J:97640 )
• congestion of the liver, lung, and spleen
cardiac hypertrophy ( J:97640 )
• at E14.5 and at birth hypertrophy of the ventricles and atria is seen

cellular
decreased cell proliferation ( J:97640 )
• cell proliferation in homozygous embryos is reduced by 20% to 30% depending on the tissue examined
• MEFs from E13.5 embryos display a significantly lower growth rate and earlier senescence compared to wild-type MEFs

homeostasis/metabolism
skin edema ( J:97640 )
• edema is seen under the skin

growth/size/body
cardiac hypertrophy ( J:97640 )
• at E14.5 and at birth hypertrophy of the ventricles and atria is seen
decreased fetal size ( J:97640 )
• at E14.5 embryos are significantly smaller and almost all major organs are proportionally smaller

hematopoietic system

immune system

liver/biliary system

integument
skin edema ( J:97640 )
• edema is seen under the skin
abnormal epidermis stratum basale morphology ( J:97640 )
• cell number and proliferation are reduced; however apoptosis is normal
pallor ( J:97640 )
• at E14.5 homozygotes are pale
thin skin ( J:97640 )
• the skin is thinner and less keratinized




Genotype
MGI:3582502
hm2
Allelic
Composition		 Morf4l1tm1Kto/Morf4l1tm1Kto
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Morf4l1tm1Kto mutation (0 available); any Morf4l1 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3582501
cx3
Allelic
Composition		 Morf4l1tm1Kto/Morf4l1tm1Kto
Morf4l2tm1.1Kto/Morf4l2tm1.1Kto
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Morf4l1tm1Kto mutation (0 available); any Morf4l1 mutation (51 available)
Morf4l2tm1.1Kto mutation (0 available); any Morf4l2 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:99130 )
• embryos are present at E10.5 but are absent at E11.5

embryo
decreased embryo size ( J:99130 )
• at E10.5 double knock out embryos are smaller than littermates

growth/size/body
decreased embryo size ( J:99130 )
• at E10.5 double knock out embryos are smaller than littermates




Genotype
MGI:3582503
cx4
Allelic
Composition		 Morf4l1tm1Kto/Morf4l1tm1Kto
Morf4l2tm1.1Kto/Y
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Morf4l1tm1Kto mutation (0 available); any Morf4l1 mutation (51 available)
Morf4l2tm1.1Kto mutation (0 available); any Morf4l2 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:99130 )
• embryos are present at E10.5 but are absent at E11.5

embryo
decreased embryo size ( J:99130 )
• at E10.5 double knock out embryos are smaller than littermates

growth/size/body
decreased embryo size ( J:99130 )
• at E10.5 double knock out embryos are smaller than littermates




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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory