About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Morf4l1tm1Kto
targeted mutation 1, Kaoru Tominaga
MGI:3576922
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Morf4l1tm1Kto/Morf4l1tm1Kto involves: 129S7/SvEvBrd MGI:3577651
hm2
 		Morf4l1tm1Kto/Morf4l1tm1Kto involves: 129S7/SvEvBrd * C57BL/6J MGI:3582502
cx3
 		Morf4l1tm1Kto/Morf4l1tm1Kto
Morf4l2tm1.1Kto/Morf4l2tm1.1Kto 		involves: 129S7/SvEvBrd * C57BL/6J MGI:3582501
cx4
 		Morf4l1tm1Kto/Morf4l1tm1Kto
Morf4l2tm1.1Kto/Y 		involves: 129S7/SvEvBrd * C57BL/6J MGI:3582503


Genotype
MGI:3577651
hm1
Allelic
Composition		 Morf4l1tm1Kto/Morf4l1tm1Kto
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Morf4l1tm1Kto mutation (0 available); any Morf4l1 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:97640 )
• only 6.7% of pups at birth are homozygous and these die shortly after birth; however the expected number of homozygous embryos are found at E14.5

muscle

respiratory system
abnormal pulmonary alveolus morphology ( J:97640 )
• alveolar space is significantly reduced in neonates
respiratory failure ( J:97640 )
• the lungs do not appear to inflate after birth

cardiovascular system
visceral vascular congestion ( J:97640 )
• congestion of the liver, lung, and spleen
cardiac hypertrophy ( J:97640 )
• at E14.5 and at birth hypertrophy of the ventricles and atria is seen

cellular
decreased cell proliferation ( J:97640 )
• cell proliferation in homozygous embryos is reduced by 20% to 30% depending on the tissue examined
• MEFs from E13.5 embryos display a significantly lower growth rate and earlier senescence compared to wild-type MEFs

homeostasis/metabolism
skin edema ( J:97640 )
• edema is seen under the skin

growth/size/body
cardiac hypertrophy ( J:97640 )
• at E14.5 and at birth hypertrophy of the ventricles and atria is seen
decreased fetal size ( J:97640 )
• at E14.5 embryos are significantly smaller and almost all major organs are proportionally smaller

hematopoietic system

immune system

liver/biliary system

integument
skin edema ( J:97640 )
• edema is seen under the skin
abnormal epidermis stratum basale morphology ( J:97640 )
• cell number and proliferation are reduced; however apoptosis is normal
pallor ( J:97640 )
• at E14.5 homozygotes are pale
thin skin ( J:97640 )
• the skin is thinner and less keratinized




Genotype
MGI:3582502
hm2
Allelic
Composition		 Morf4l1tm1Kto/Morf4l1tm1Kto
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Morf4l1tm1Kto mutation (0 available); any Morf4l1 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3582501
cx3
Allelic
Composition		 Morf4l1tm1Kto/Morf4l1tm1Kto
Morf4l2tm1.1Kto/Morf4l2tm1.1Kto
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Morf4l1tm1Kto mutation (0 available); any Morf4l1 mutation (51 available)
Morf4l2tm1.1Kto mutation (0 available); any Morf4l2 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:99130 )
• embryos are present at E10.5 but are absent at E11.5

embryo
decreased embryo size ( J:99130 )
• at E10.5 double knock out embryos are smaller than littermates

growth/size/body
decreased embryo size ( J:99130 )
• at E10.5 double knock out embryos are smaller than littermates




Genotype
MGI:3582503
cx4
Allelic
Composition		 Morf4l1tm1Kto/Morf4l1tm1Kto
Morf4l2tm1.1Kto/Y
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Morf4l1tm1Kto mutation (0 available); any Morf4l1 mutation (51 available)
Morf4l2tm1.1Kto mutation (0 available); any Morf4l2 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:99130 )
• embryos are present at E10.5 but are absent at E11.5

embryo
decreased embryo size ( J:99130 )
• at E10.5 double knock out embryos are smaller than littermates

growth/size/body
decreased embryo size ( J:99130 )
• at E10.5 double knock out embryos are smaller than littermates




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory