Phenotypes associated with this allele

• Allele Symbol: Il1rn^tm1Sush
• Allele Name: targeted mutation 1, Kouji Matsushima
• Allele ID: MGI:3576926
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il1rn^tm1Sush/Il1rn^tm1Sush	involves: 129P2/OlaHsd * C57BL/6	MGI:3582775

Genotype
MGI:3582775

hm1

• Allelic Composition: Il1rn^tm1Sush/Il1rn^tm1Sush
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal dendritic cell differentiation ( J:97684 )

abnormal dendritic cell number ( J:97684 )

• increased levels of immature dendritic cells

• decreased levels of mature dendritic cells

abnormal CD4-positive, alpha beta T cell morphology ( J:97684 )

abnormal T-helper 1 cell morphology ( J:97684 )

• induction indicated by cytokine expression

abnormal T-helper 2 cell morphology ( J:97684 )

• induction indicated by cytokine expression

abnormal immune system organ morphology ( J:97684 )

• formation of Portal-Tract associated lymphoid tissue is reduced

granulomatous inflammation ( J:97684 )

• enhanced formation of intrahepatic granulomas after infection with Propionibacterium acnes

• 2 fold increase in infiltrated area

hematopoietic system

abnormal dendritic cell differentiation ( J:97684 )

abnormal dendritic cell number ( J:97684 )

• increased levels of immature dendritic cells

• decreased levels of mature dendritic cells

abnormal CD4-positive, alpha beta T cell morphology ( J:97684 )

abnormal T-helper 1 cell morphology ( J:97684 )

• induction indicated by cytokine expression

abnormal T-helper 2 cell morphology ( J:97684 )

• induction indicated by cytokine expression

cellular

abnormal dendritic cell differentiation ( J:97684 )