Phenotypes associated with this allele

• Allele Symbol: Dicer1^tm1Gz
• Allele Name: targeted mutation 1, Genshi Zhao
• Allele ID: MGI:3576927
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dicer1^tm1Gz/Dicer1^tm1Gz	involves: 129P2/OlaHsd * C57BL/6	MGI:3577190

Genotype
MGI:3577190

hm1

• Allelic Composition: Dicer1^tm1Gz/Dicer1^tm1Gz
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:97770 )

• homozygous embryos die between E12.5 and E14.5

cardiovascular system

abnormal blood vessel morphology ( J:97770 )

• at E13.5 - E14.5, blood vessels are thin and poorly developed and the embryos appear pale

abnormal angiogenesis ( J:97770 )

• at E14.5, the normal vascular branching structure is absent, instead many disorganized vascular structures are seen

absent vitelline blood vessels ( J:97770 )

• in extreme cases no blood vessels are seen on the yolk sac

embryo

absent vitelline blood vessels ( J:97770 )

• in extreme cases no blood vessels are seen on the yolk sac

decreased embryo size ( J:97770 )

• at E12.5 mutants are smaller and slightly underdeveloped

abnormal vitelline vascular remodeling ( J:97770 )

• the primitive vascular plexus forms but by E10.5 the yolk sac has fewer, thin, small and poorly organized vessels

liver/biliary system

small liver ( J:97770 )

• at E13.5 - E14.5 the liver is smaller

growth/size/body

decreased embryo size ( J:97770 )

• at E12.5 mutants are smaller and slightly underdeveloped