Phenotypes associated with this allele

• Allele Symbol: Pcsk9^tm1Jdh
• Allele Name: targeted mutation 1, Jay D Horton
• Allele ID: MGI:3577021
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pcsk9^tm1Jdh/Pcsk9^tm1Jdh	involves: 129S6/SvEvTac	MGI:3577440

Genotype
MGI:3577440

hm1

• Allelic Composition: Pcsk9^tm1Jdh/Pcsk9^tm1Jdh
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating cholesterol level ( J:97836 )

• plasma cholesterol levels were 48% lower than in wildtype, despite similar levels of plasma triglycerides

• plasma cholesterol levels decreased even more with the addition of lovastatin to the diet

decreased circulating HDL cholesterol level ( J:97836 )

• 30% reduction in plasma HDL cholesterol levels

decreased circulating LDL cholesterol level ( J:97836 )

• additional 2-fold increase in the rate of labeled LDL cholesterol clearance from plasma when lovastatin was added to the diet

• nearly undetectable levels of plasma LDL cholesterol levels

• 5-fold increase in the rate of labeled LDL cholesterol clearance from plasma (12 min to clear 50% of LDL versus more than 60 min in wildtype)