About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rbbp8tm1Whl
targeted mutation 1, Wen-Hwa Lee
MGI:3577029
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rbbp8tm1Whl/Rbbp8tm1Whl Not Specified MGI:3577102
ht2
 		Rbbp8tm1Whl/Rbbp8+ Not Specified MGI:3577103
cn3
 		Rbbp8tm1Whl/Rbbp8tm1.1Thl
Cd19tm1(cre)Cgn/Cd19+ 		involves: 129P2/OlaHsd * 129S4/SvJaeSor MGI:5484529


Genotype
MGI:3577102
hm1
Allelic
Composition		 Rbbp8tm1Whl/Rbbp8tm1Whl
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbbp8tm1Whl mutation (0 available); any Rbbp8 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality before implantation, complete penetrance ( J:97648 )
• homozygotes die at E4 because blastocysts fail to enter S phase

embryo
failure of blastocyst to hatch from the zona pellucida ( J:97648 )
• homozygous blastocysts in culture fail to hatch from the zona pellucida
embryonic growth arrest ( J:97648 )
• homozygous blastocysts in culture show no outgrowth
absent egg cylinders ( J:97648 )
• homozygous embryos fail to form egg cylinders and degenerate in the uterus

cellular
abnormal cell cycle ( J:97648 )
• cells from homozygous blastocysts fail to proliferate and arrest at G1




Genotype
MGI:3577103
ht2
Allelic
Composition		 Rbbp8tm1Whl/Rbbp8+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbbp8tm1Whl mutation (0 available); any Rbbp8 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased tumor-free survival time ( J:97648 )
• heterozygotes die around day 625 with multiple tumors, wild-type littermates die around day 780

neoplasm
increased lymphoma incidence ( J:97648 )
• multiple tumors, predominantly large lymphomas of both B and T cells are seen in older heterozygotes
• tumors all retain a wild-type copy of Rbbp8




Genotype
MGI:5484529
cn3
Allelic
Composition		 Rbbp8tm1Whl/Rbbp8tm1.1Thl
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Rbbp8tm1.1Thl mutation (0 available); any Rbbp8 mutation (51 available)
Rbbp8tm1Whl mutation (0 available); any Rbbp8 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:194603 )
N
• B cells exhibit normal class switching and microhomology at Smu-Sgamma1 junctions




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory