Phenotypes associated with this allele

• Allele Symbol: Sema5a^tm1Awp
• Allele Name: targeted mutation 1, Andreas W Puschel
• Allele ID: MGI:3577050
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sema5a^tm1Awp/Sema5a^tm1Awp	involves: 129S1/Sv * 129X1/SvJ * NMRI	MGI:3577361

Genotype
MGI:3577361

hm1

• Allelic Composition: Sema5a^tm1Awp/Sema5a^tm1Awp
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:97663 )

• die between E11.5 and E12.5

cardiovascular system

abnormal blood vessel morphology ( J:97663 )

• decrease in the number of large-diameter vessels in the cranial region at E10.5, however development of extraembryonic tissues, the heart, and the peripheral nervous system was normal

abnormal vascular branching morphogenesis ( J:97663 )

• cranial large vessels did not form additional branches and failed to establish their normal hierarchical organization, however the number of primary branches sprouting from the cardinal veins was unaltered at E10.5 but was reduced at E11.5