All Phenotypes Irf7<tm1Ttg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Irf7^tm1Ttg
targeted mutation 1, Tadatsugu Taniguchi
MGI:3577089

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Irf7^tm1Ttg/Irf7^tm1Ttg	B6.129P2-Irf7^tm1Ttg	MGI:5828535
hm2	Irf7^tm1Ttg/Irf7^tm1Ttg	involves: 129P2/OlaHsd	MGI:3577711
cx3	Irf3^tm1Ttg/Irf3^tm1Ttg Irf7^tm1Ttg/Irf7^tm1Ttg	involves: 129P2/OlaHsd * 129S/SvEv	MGI:4442206

Allelic Composition	Irf7^tm1Ttg/Irf7^tm1Ttg
Genetic Background	B6.129P2-Irf7^tm1Ttg

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf7^tm1Ttg mutation (2 available); any Irf7 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:233979 )

• in PR8M virus-infected mice

immune system

increased susceptibility to Orthomyxoviridae infection ( J:233979 )

• a low pathogenic A/Puerto Rico/8/1934 H1N1 (PR8M) virus-infected mice exhibit increased weight loss and mortality compared with wild-type mice

increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:233979 )

• in PR8M virus-infected mice

Allelic Composition	Irf7^tm1Ttg/Irf7^tm1Ttg
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf7^tm1Ttg mutation (2 available); any Irf7 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell physiology ( J:97662 )

• induction of the antigen-specific CD8+ T-cell response by immunizing with soluble ovalbumin and TLR9 agonists, but not TLR2 and TLR6 agonisits, was severely impaired

abnormal interferon level ( J:97662 )

• reduced total type-1 interferon (IFN) activity in the supernatant of mutant MEFs infected with herpes simplex virus type 1 (HSV-1), encephalomyocarditis virus (EMCV) or vesicular stomatitis virus (VSV) compared to controls

• decrease in serum type-1 IFN levels after viral infection (with HSV-1 or EMCV)

increased susceptibility to Herpesvirales infection ( J:97662 )

• more vulnerable to HSV-1 infection than wild-type or homozygous Irf3 or Myd88 mutant mice

increased susceptibility to Picornaviridae infection ( J:97662 )

• more vulnerable to EMCV infection than wild-type or homozygous Irf3 or Myd88 mutant mice

homeostasis/metabolism

abnormal interferon level ( J:97662 )

• decrease in serum type-1 IFN levels after viral infection (with HSV-1 or EMCV)

hematopoietic system

abnormal T cell physiology ( J:97662 )

• induction of the antigen-specific CD8+ T-cell response by immunizing with soluble ovalbumin and TLR9 agonists, but not TLR2 and TLR6 agonisits, was severely impaired

Allelic Composition	Irf3^tm1Ttg/Irf3^tm1Ttg Irf7^tm1Ttg/Irf7^tm1Ttg
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf3^tm1Ttg mutation (3 available); any Irf3 mutation (37 available)
Irf7^tm1Ttg mutation (2 available); any Irf7 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased interferon-beta secretion ( J:158969 )

• F. tularensis live vaccine strain-, Sendai virus-, or synthetic B-form dsDNA (poly-dA:dT)-treated thioglycollate-elicited macrophages secrete less IFN-beta than similarly treated wild-type cells

• mCMV-treated thioglycollate-elicited macrophages fail to secrete IFN-beta unlike similarly treated wild-type cells

decreased interleukin-1 beta secretion ( J:158969 )

• F. tularensis live vaccine strain-treated thioglycollate-elicited macrophages secrete less IL1B than similarly treated wild-type cells

• however, synthetic B-form dsDNA (poly-dA:dT)-treated mice produce normal amounts of IL1-beta

increased susceptibility to bacterial infection ( J:158969 )

• F. tularensis live vaccine strain-treated thioglycollate-elicited macrophages secrete less IL1B and IFN-beta than similarly treated wild-type cells

increased susceptibility to Herpesvirales infection ( J:158969 )

• mCMV-treated thioglycollate-elicited macrophages fail to secrete IFN-beta unlike similarly treated wild-type cells

increased susceptibility to Paramyxoviridae infection ( J:158969 )

• Sendai virus-treated splenocytes secrete less IFN-beta than similarly treated wild-type cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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