Phenotypes associated with this allele

• Allele Symbol: Tg(Tagln-cre)1Jjl
• Allele Name: transgene insertion 1, John J Lepore
• Allele ID: MGI:3577106
• Summary: 8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Senp1^tm1Wami/Senp1^tm1Wami Tg(Tagln-cre)1Jjl/0	involves: 129 * C57BL/6 * FVB/N	MGI:5707799
cn2	Apoe^tm1Unc/Apoe^tm1Unc Klf15^tm2Jain/Klf15^tm2Jain Tg(Tagln-cre)1Jjl/0	involves: 129P2/OlaHsd * FVB/N	MGI:5552967
cn3	Gata6^tm2Msp/Gata6^tm2Msp Tg(Tagln-cre)1Jjl/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	MGI:3623950
cn4	Gt(ROSA)26Sor^tm4(ACTB-tdTomato,-EGFP)Luo/? Smo^tm2Amc/Smo^tm2Amc Tg(Tagln-cre)1Jjl/0	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:5563909
cn5	Pkn2^tm1c(KOMP)Wtsi/Pkn2^tm1c(KOMP)Wtsi Tg(Tagln-cre)1Jjl/0	involves: C57BL/6N * FVB/N	MGI:5912010
cn6	Gt(ROSA)26Sor^tm1(MAML1)Wsp/Gt(ROSA)26Sor^+ Tg(Tagln-cre)1Jjl/0	involves: CD-1 * FVB/N	MGI:3691131
cn7	Klf15^tm2Jain/Klf15^tm2Jain Tg(Tagln-cre)1Jjl/0	involves: FVB/N	MGI:5552966
cn8	Ccm2^tm1Kwhi/Ccm2^tm1.1Kwhi Tg(Tagln-cre)1Jjl/0	involves: FVB/N	MGI:3838805

Genotype
MGI:5707799

cn1

• Allelic Composition: Senp1^tm1Wami/Senp1^tm1Wami; Tg(Tagln-cre)1Jjl/0
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:228009 )

N • mice do not develop hyperglycemia even at 14 weeks of age

Genotype
MGI:5552967

cn2

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Klf15^tm2Jain/Klf15^tm2Jain; Tg(Tagln-cre)1Jjl/0
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

Klf15^tm2Jain/Klf15^tm2Jain Tg(Tagln-cre)1Jjl/0 Apoe^tm1Unc/Apoe^tm1Unc aortas develop more atherosclerotic lesions after a high fat diet challenge

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:203920 )

N • mice fed a high fat diet exhibit the same circulating levels of cholesterol and triglycerides as in Apoe^tm1Unc homozygotes

immune system

blood vessel inflammation ( J:203920 )

• increased macrophage in the aortic wall and atherosclerotic lesions of mice fed a high fat diet with Apoe^tm1Unc homozygotes

increased macrophage cell number ( J:203920 )

• increased macrophage in the aortic wall and atherosclerotic lesions of mice fed a high fat diet with Apoe^tm1Unc homozygotes

cardiovascular system

increased susceptibility to atherosclerosis ( J:203920 )

• in mice fed a high fat diet compared with Apoe^tm1Unc homozygotes

vascular smooth muscle hypoplasia ( J:203920 )

• decreased vascular smooth muscle cells in the aortic wall and atherosclerotic lesions of mice fed a high fat diet with Apoe^tm1Unc homozygotes

blood vessel inflammation ( J:203920 )

• increased macrophage in the aortic wall and atherosclerotic lesions of mice fed a high fat diet with Apoe^tm1Unc homozygotes

muscle

vascular smooth muscle hypoplasia ( J:203920 )

• decreased vascular smooth muscle cells in the aortic wall and atherosclerotic lesions of mice fed a high fat diet with Apoe^tm1Unc homozygotes

hematopoietic system

increased macrophage cell number ( J:203920 )

• increased macrophage in the aortic wall and atherosclerotic lesions of mice fed a high fat diet with Apoe^tm1Unc homozygotes

Genotype
MGI:3623950

cn3

• Allelic Composition: Gata6^tm2Msp/Gata6^tm2Msp; Tg(Tagln-cre)1Jjl/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

mortality/aging

perinatal lethality, complete penetrance ( J:107814 )

• all die between E18.5 and P2

cardiovascular system

retroesophageal right subclavian artery ( J:107814 )

• 6 of 11 embryos show a retroesophageal right subclavian artery

aortic arch hypoplasia ( J:107814 )

• 7 of 11 embryos exhibit a hypoplastic aortic arch

interrupted aortic arch ( J:107814 )

• 7 of 11 embryos have an interrupted aortic arch

absent fetal ductus arteriosus ( J:107814 )

• seen in 1/11 mutant mice

persistent truncus arteriosus ( J:107814 )

• seen in 7 of 11 embryos

double outlet right ventricle ( J:107814 )

• seen in 4 of 11 embryos

perimembraneous ventricular septal defect ( J:107814 )

• all embryos exhibit a membranous ventricular septal defect

homeostasis/metabolism

cyanosis ( J:107814 )

• several newborns are cyanotic and expire shortly after birth

Genotype
MGI:5563909

cn4

• Allelic Composition: Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/?; Smo^tm2Amc/Smo^tm2Amc; Tg(Tagln-cre)1Jjl/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

cardiovascular system

cardiovascular system phenotype ( J:204743 )

N • cardiopulmonary development is not disrupted

Genotype
MGI:5912010

cn5

• Allelic Composition: Pkn2^{tm1c(KOMP)Wtsi}/Pkn2^{tm1c(KOMP)Wtsi}; Tg(Tagln-cre)1Jjl/0
• Genetic Background: involves: C57BL/6N * FVB/N

mortality/aging

lethality, incomplete penetrance ( J:229595 )

cardiovascular system

cardiac hypertrophy ( J:229595 )

• in survivors

respiratory system

overexpanded pulmonary alveolus ( J:229595 )

• alveolar enlargement in survivors

pulmonary fibrosis ( J:229595 )

• in survivors

growth/size/body

cardiac hypertrophy ( J:229595 )

• in survivors

Genotype
MGI:3691131

cn6

• Allelic Composition: Gt(ROSA)26Sor^{tm1(MAML1)Wsp}/Gt(ROSA)26Sor⁺; Tg(Tagln-cre)1Jjl/0
• Genetic Background: involves: CD-1 * FVB/N

growth/size/body

dermal cyst ( J:112093 )

• keratin cyst formation is observed

decreased body size ( J:112093 )

• generalized growth retardation is observed compared to controls

neoplasm

increased squamous cell carcinoma incidence ( J:112093 )

• mice develop spontaneous cutaneous SCC lesions, as well as dysplastic precursor lesions

limbs/digits/tail

abnormal tail morphology ( J:112093 )

• with aging, hyperkeratinization of tail is seen

integument

abnormal hair growth ( J:112093 )

• aberrant hair follicle cycling occurs

alopecia ( J:112093 )

• starting at 2-3 weeks, mice display hair and whisker loss; diffuse alopecia is observed

• at 10 months of age, alopecia has progressed almost to completion

abnormal dermal layer morphology ( J:112093 )

• hypoplastic dermis with increased cellularity is observed

• by 6 months of age, most mice develop hyperkeratotic cutaneous nodules, with all mutants exhibiting multiple lesions by 10 months of age

• examination of some nodules reveals papillomas or inflamed infundibular cyts

dermal cyst ( J:112093 )

• keratin cyst formation is observed

abnormal keratinocyte morphology ( J:112093 )

• cutaneous nodules show hyperproliferative keratinocytic lesions exhibiting cellular atypia and an invasive growth pattern

Genotype
MGI:5552966

cn7

• Allelic Composition: Klf15^tm2Jain/Klf15^tm2Jain; Tg(Tagln-cre)1Jjl/0
• Genetic Background: involves: FVB/N

mortality/aging

mortality/aging ( J:203920 )

N • mice are viable and born in expected Mendelian ratios

Genotype
MGI:3838805

cn8

• Allelic Composition: Ccm2^tm1Kwhi/Ccm2^tm1.1Kwhi; Tg(Tagln-cre)1Jjl/0
• Genetic Background: involves: FVB/N

normal phenotype

no abnormal phenotype detected ( J:146527 )

• no vasculature defects are observed during development

• homozygote mice are born at the expected ratios