All Phenotypes Polh<tm1Crey> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Polh^tm1Crey
targeted mutation 1, Claude-Agnes Reynaud
MGI:3577345

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Polh^tm1Crey/Polh^tm1Crey	involves: 129P2/OlaHsd * C57BL/6	MGI:3579244
cx2	Polh^tm1Crey/Polh^tm1Crey Poli^d/Poli^d	involves: 129P2/OlaHsd * C57BL/6	MGI:3579249

Allelic Composition	Polh^tm1Crey/Polh^tm1Crey
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polh^tm1Crey mutation (2 available); any Polh mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell physiology ( J:98037 )

• no B cell anomalies were observed

• Ig sequences from mutant mice PNA ^highB cells displayed the 85% G/C biased pattern mutation similar to that reported for XP-V patients

hematopoietic system

abnormal B cell physiology ( J:98037 )

• no B cell anomalies were observed

• Ig sequences from mutant mice PNA ^highB cells displayed the 85% G/C biased pattern mutation similar to that reported for XP-V patients

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
xeroderma pigmentosum variant type		DOID:0110847	OMIM:278750	J:98037

Allelic Composition	Polh^tm1Crey/Polh^tm1Crey Poli^d/Poli^d
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polh^tm1Crey mutation (2 available); any Polh mutation (38 available)
Poli^d mutation (3 available); any Poli mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell physiology ( J:98037 )

• no B cell anomalies were observed

• Ig sequences from mutant mice PNA ^highB cells displayed the 85% G/C biased pattern mutation similar to that reported for XP-V patients

hematopoietic system

abnormal B cell physiology ( J:98037 )

• no B cell anomalies were observed

• Ig sequences from mutant mice PNA ^highB cells displayed the 85% G/C biased pattern mutation similar to that reported for XP-V patients

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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