Phenotypes associated with this allele

• Allele Symbol: Grid2^{tm1(cre/PGR*)Ksak}
• Allele Name: targeted mutation 1, Kenji Sakimura
• Allele ID: MGI:3577356
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grid2^tm1(cre/PGR*)Ksak/Grid2^tm1(cre/PGR*)Ksak	C57BL/6-Grid2^tm1(cre/PGR*)Ksak	MGI:3851248
cn2	Grid2^tm1(cre/PGR*)Ksak/Grid2^tm2Mim	involves: C57BL/6	MGI:3577393

Genotype
MGI:3851248

hm1

• Allelic Composition: Grid2^{tm1(cre/PGR*)Ksak}/Grid2^{tm1(cre/PGR*)Ksak}
• Genetic Background: C57BL/6-Grid2^{tm1(cre/PGR*)Ksak}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

ataxia ( J:150621 )

• mice have a severely ataxic gait and cannot walk with regular steps

impaired coordination ( J:150621 )

• on a rotarod

Genotype
MGI:3577393

cn2

• Allelic Composition: Grid2^{tm1(cre/PGR*)Ksak}/Grid2^tm2Mim
• Genetic Background: involves: C57BL/6

nervous system

abnormal Purkinje cell morphology ( J:97405 )

• upon induction of loxP-cre mediated recombinations by administration of the synthetic steroid, RU486 in Purkinje cells of the mutant mice cerebellum, following phenotype were observed

• presynaptic active zones shrank progressively and postsynaptic density expanded, resulting in mismatching between presynaptic and postsynaptic specializations at parallel fiber-Purkinje cell synapses

• when glutamate receptor gamma 2 proteins were diminished, Purkinje cell spines lost their synaptic contacts