Phenotypes associated with this allele

• Allele Symbol: Rere^eyes3
• Allele Name: eyes 3
• Allele ID: MGI:3577419
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rere^eyes3/Rere^eyes3	involves: C57BL/6	MGI:3577769
ht2	Rere^eyes3/Rere^om	B6.Cg-Rere^eyes3/Rere^om	MGI:5503951
ht3	Rere^eyes3/Rere^om	involves: 129S6/SvEvTac * BTBR * C57BL/6	MGI:5503952

Genotype
MGI:3577769

hm1

• Allelic Composition: Rere^eyes3/Rere^eyes3
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Microphthalmia in Rere^eyes3/Rere^eyes3 mice

growth/size/body

narrow snout ( J:89098 )

• snouts described as narrower than controls

decreased body size ( J:89098 )

• slightly smaller than controls

decreased body weight ( J:199403 )

• at 3, 7 and 10 weeks of age

craniofacial

narrow snout ( J:89098 )

• snouts described as narrower than controls

vision/eye

microphthalmia ( J:89098 , J:199403 )

• unilateral or bilateral (J:199403)

renal/urinary system

absent kidney ( J:199403 )

Genotype
MGI:5503951

ht2

• Allelic Composition: Rere^eyes3/Rere^om
• Genetic Background: B6.Cg-Rere^eyes3/Rere^om

Cardiovascular malformations in Rere^om/Rere^eyes3 embryos on a C57BL6 background

mortality/aging

perinatal lethality, complete penetrance ( J:306308 )

• on a B6 background, mice are reported to exhibit perinatal lethality with no pups recovered at P0

• however, fetuses are found at Mendelian ratios at E15.5

cardiovascular system

abnormal pulmonary artery morphology ( J:199403 )

• in 2 of 6 mice

abnormal aortic arch morphology ( J:199403 )

• in 4 of 6 mice

right aortic arch ( J:199403 )

• in 3 of 6 mice

abnormal left subclavian artery morphology ( J:199403 )

• in 3 of 6 mice

abnormal right subclavian artery morphology ( J:199403 )

• in 1 of 6 mice

abnormal cardiovascular development ( J:199403 )

• Background Sensitivity: cardiovascular malformation in 6 of 6 mice on a congenic C57BL/6 background unlike mice on a mixed background

double outlet right ventricle ( J:199403 )

• in 3 of 6 mice

transposition of great arteries ( J:199403 )

• in 1 of 6 mice

perimembraneous ventricular septal defect ( J:199403 )

cardiac fibrosis ( J:199403 )

• in the myocardium of the ventricle wall of adult mice

renal/urinary system

absent kidney ( J:199403 )

• in 10 of 35 mice at P0

single kidney ( J:199403 )

• in 3 of 35 mice at P0

craniofacial

palatal shelves fail to meet at midline ( J:306308 )

• at E15.5, palate shelves fail to contact each other in the midline

median cleft palate ( J:306308 )

• at E15.5, cleft palate is detected in the midline from the anterior region to the posterior region in 80% of mice

digestive/alimentary system

palatal shelves fail to meet at midline ( J:306308 )

• at E15.5, palate shelves fail to contact each other in the midline

median cleft palate ( J:306308 )

• at E15.5, cleft palate is detected in the midline from the anterior region to the posterior region in 80% of mice

growth/size/body

palatal shelves fail to meet at midline ( J:306308 )

• at E15.5, palate shelves fail to contact each other in the midline

median cleft palate ( J:306308 )

• at E15.5, cleft palate is detected in the midline from the anterior region to the posterior region in 80% of mice

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:199403 )

N • mice with renal agenesis exhibit normal adrenal glands

Genotype
MGI:5503952

ht3

• Allelic Composition: Rere^eyes3/Rere^om
• Genetic Background: involves: 129S6/SvEvTac * BTBR * C57BL/6

Severe microphthalmia in Rere^eyes3/Rere^om mice

mortality/aging

postnatal lethality, incomplete penetrance ( J:199403 )

• despite being born in Mendelian ratios, most mice die before weaning

nervous system

nervous system phenotype ( J:199403 )

N • neuron proliferation, apoptosis and maturation of granule cells are normal

decreased brain size ( J:199403 )

• at P0

decreased brain weight ( J:199403 )

• at E17.5, E18.5 and P0

abnormal cerebral hemisphere morphology ( J:199403 )

• reduced surface area of the cerebral hemispheres at E17.0 and P0

abnormal hippocampus neuron morphology ( J:199403 )

• decreased NeuN+ hippocampal neurons at E18.5 in the Ammon's horn

• however, the number of NeuN+ neurons in the dentate gyrus is normal

abnormal cerebellum morphology ( J:199403 )

• reduced surface area of the cerebellum at E17.0 and P0

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:199403 )

• at P21

impaired hearing ( J:199403 )

• at P21

growth/size/body

decreased body weight ( J:199403 )

• despite normal birth weight, mice weight less at P7 compared with wild-type mice

postnatal growth retardation ( J:199403 )

• body weights plateau at 6 weeks of age unlike wild-type mice

vision/eye

microphthalmia ( J:199403 )

• unilateral or bilateral; more severe than in Rere^eyes3 homozygotes

cardiovascular system

cardiovascular system phenotype ( J:199403 )

N • mice on a mixed background exhibit normal cardiovascular morphology unlike mice on a congenic C57BL/6 background