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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lrp6skax26
skeletal/axial 26
MGI:3577510
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lrp6skax26/Lrp6skax26 involves: 129S6/SvEvTac * C57BL/6J MGI:5571492
hm2
 		Lrp6skax26/Lrp6skax26 involves: C57BL/6J MGI:5007813
ht3
 		Lrp6skax26/Lrp6+ involves: 129S6/SvEvTac * C57BL/6J MGI:5571493
cx4
 		Lrp6skax26/Lrp6+
Vangl2Lp/Vangl2+ 		involves: A/J * 129S6/SvEvTac * C57BL/6 * C57BL/6J MGI:5571494


Genotype
MGI:5571492
hm1
Allelic
Composition		 Lrp6skax26/Lrp6skax26
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp6skax26 mutation (0 available); any Lrp6 mutation (95 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
abnormal orientation of outer hair cell stereociliary bundles ( J:206979 )
• only in the OHC3 layer of the apical region

limbs/digits/tail
curly tail ( J:206979 )
• kinky/looped tail in most mice
kinked tail ( J:206979 )
• kinky/looped tail in most mice

nervous system
abnormal orientation of outer hair cell stereociliary bundles ( J:206979 )
• only in the OHC3 layer of the apical region




Genotype
MGI:5007813
hm2
Allelic
Composition		 Lrp6skax26/Lrp6skax26
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp6skax26 mutation (0 available); any Lrp6 mutation (95 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
curly tail ( J:89098 )
• described as a loop tail, variable penetrance
kinked tail ( J:89098 )
• described as a kinky tail after an outcross




Genotype
MGI:5571493
ht3
Allelic
Composition		 Lrp6skax26/Lrp6+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp6skax26 mutation (0 available); any Lrp6 mutation (95 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
curly tail ( J:206979 )
• kinky/looped tail in a few mice
kinked tail ( J:206979 )
• kinky/looped tail in a few mice




Genotype
MGI:5571494
cx4
Allelic
Composition		 Lrp6skax26/Lrp6+
Vangl2Lp/Vangl2+
Genetic
Background		 involves: A/J * 129S6/SvEvTac * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp6skax26 mutation (0 available); any Lrp6 mutation (95 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
abnormal orientation of outer hair cell stereociliary bundles ( J:206979 )
• everely affected in OHC2 and OHC3 layers at all three regions analyzed except for OHC3 in the middle region of the organ of Corti

limbs/digits/tail
curly tail ( J:206979 )
• kinky/looped tail in most mice
kinked tail ( J:206979 )
• kinky/looped tail in most mice

embryo
spina bifida ( J:206979 )
• in some mice unlike single heterozygotes

nervous system
spina bifida ( J:206979 )
• in some mice unlike single heterozygotes
abnormal orientation of outer hair cell stereociliary bundles ( J:206979 )
• everely affected in OHC2 and OHC3 layers at all three regions analyzed except for OHC3 in the middle region of the organ of Corti




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory